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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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IGF2R
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    TISSUE

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    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

IGF2R

Gene description

Insulin-like growth factor 2 receptor

Protein class

Cancer-related genes
CD markers
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA011332 , CAB009661
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

IGF2R (HGNC Symbol)

Synonyms

CD222, CIMPR, M6P-R, MPR1, MPRI

Description

Insulin-like growth factor 2 receptor (HGNC Symbol)

Entrez gene summary

This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]

Chromosome

6

Cytoband

q25.3

Chromosome location (bp)

159969099 - 160113507

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197081 (version 83.38)

Entrez gene

3482

UniProt

P11717 (UniProt - Evidence at protein level)

neXtProt

NX_P11717

Antibodypedia

IGF2R antibodies

PROTEIN BROWSER

IGF2R-001
IGF2R-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IGF2R-001
ENSP00000349437
ENST00000356956
P11717 [Direct mapping]
Cation-independent mannose-6-phosphate receptor
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001889 [liver development]
GO:0001948 [glycoprotein binding]
GO:0001965 [G-protein alpha-subunit binding]
GO:0001972 [retinoic acid binding]
GO:0004872 [receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005010 [insulin-like growth factor-activated receptor activity]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005520 [insulin-like growth factor binding]
GO:0005537 [mannose binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005641 [nuclear envelope lumen]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006810 [transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007283 [spermatogenesis]
GO:0009791 [post-embryonic development]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019899 [enzyme binding]
GO:0030118 [clathrin coat]
GO:0030139 [endocytic vesicle]
GO:0030140 [trans-Golgi network transport vesicle]
GO:0031100 [organ regeneration]
GO:0031995 [insulin-like growth factor II binding]
GO:0032526 [response to retinoic acid]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051219 [phosphoprotein binding]
GO:0070062 [extracellular exosome]
Show all
2491 aa
274.4 kDa
Yes 1
IGF2R-005
ENSP00000473880
ENST00000475834
S4R328 [Direct mapping]
Cation-independent mannose-6-phosphate receptor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005737 [cytoplasm]
GO:0006810 [transport]
GO:0016021 [integral component of membrane]
Show all
185 aa
20.4 kDa
No 0

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