Expression of GAL3ST4 in cancer - Summary - The Human Protein Atlas

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GAL3ST4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GAL3ST4
Gene description	Galactose-3-O-sulfotransferase 4
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (WM-115)
HPA (normal tissue):	Tissue enhanced (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA038137
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (unfavourable), renal cancer (unfavourable) and colorectal cancer (unfavourable).
Ovarian cancer p<0.001 Renal cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038137

GENE INFORMATION
Gene name	GAL3ST4 (HGNC Symbol)
Synonyms	FLJ12116
Description	Galactose-3-O-sulfotransferase 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate to the C-3' position of galactose residues in O-linked glycoproteins. This enzyme is highly specific for core 1 structures, with asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc being good substrates. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	100159244 - 100168750
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197093 (version 83.38)
Entrez gene	79690
UniProt	Q96RP7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96RP7
Antibodypedia	GAL3ST4 antibodies

PROTEIN BROWSER

GAL3ST4-001	GAL3ST4-002	GAL3ST4-003	GAL3ST4-004	GAL3ST4-006	GAL3ST4-007	GAL3ST4-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GAL3ST4-001 ENSP00000353142 ENST00000360039	Q96RP7 [Direct mapping] Galactose-3-O-sulfotransferase 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001733 [galactosylceramide sulfotransferase activity] GO:0006790 [sulfur compound metabolic process] GO:0007267 [cell-cell signaling] GO:0009100 [glycoprotein metabolic process] GO:0009311 [oligosaccharide metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030166 [proteoglycan biosynthetic process] GO:0032580 [Golgi cisterna membrane] GO:0050656 [3'-phosphoadenosine 5'-phosphosulfate binding] GO:0050694 [galactose 3-O-sulfotransferase activity] GO:0050698 [proteoglycan sulfotransferase activity] GO:0070062 [extracellular exosome] Show all	486 aa 54.2 kDa	No	1
GAL3ST4-002 ENSP00000399066 ENST00000423751	C9IZ77 [Direct mapping] Galactose-3-O-sulfotransferase 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	220 aa 24.3 kDa	No	2
GAL3ST4-003 ENSP00000400451 ENST00000413800	Q96RP7 [Direct mapping] Galactose-3-O-sulfotransferase 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001733 [galactosylceramide sulfotransferase activity] GO:0006790 [sulfur compound metabolic process] GO:0007267 [cell-cell signaling] GO:0009100 [glycoprotein metabolic process] GO:0009311 [oligosaccharide metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030166 [proteoglycan biosynthetic process] GO:0032580 [Golgi cisterna membrane] GO:0050656 [3'-phosphoadenosine 5'-phosphosulfate binding] GO:0050694 [galactose 3-O-sulfotransferase activity] GO:0050698 [proteoglycan sulfotransferase activity] GO:0070062 [extracellular exosome] Show all	486 aa 54.2 kDa	No	1
GAL3ST4-004 ENSP00000414733 ENST00000411994	C9IZ77 [Direct mapping] Galactose-3-O-sulfotransferase 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	220 aa 24.3 kDa	No	2
GAL3ST4-006 ENSP00000488800 ENST00000460995		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		110 aa 12.1 kDa	No	1
GAL3ST4-007 ENSP00000487594 ENST00000482469		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		133 aa 14.7 kDa	No	1
GAL3ST4-008 ENSP00000488586 ENST00000498000		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		118 aa 12.9 kDa	No	1

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