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This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005080 [protein kinase C binding] GO:0005102 [receptor binding] GO:0005158 [insulin receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005829 [cytosol] GO:0005884 [actin filament] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008022 [protein C-terminus binding] GO:0008283 [cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009612 [response to mechanical stimulus] GO:0009615 [response to virus] GO:0010447 [response to acidic pH] GO:0010628 [positive regulation of gene expression] GO:0010632 [regulation of epithelial cell migration] GO:0010634 [positive regulation of epithelial cell migration] GO:0010641 [positive regulation of platelet-derived growth factor receptor signaling pathway] GO:0010907 [positive regulation of glucose metabolic process] GO:0014069 [postsynaptic density] GO:0014911 [positive regulation of smooth muscle cell migration] GO:0016032 [viral process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016337 [single organismal cell-cell adhesion] GO:0016477 [cell migration] GO:0018105 [peptidyl-serine phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019901 [protein kinase binding] GO:0019904 [protein domain specific binding] GO:0020037 [heme binding] GO:0022407 [regulation of cell-cell adhesion] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0030331 [estrogen receptor binding] GO:0030900 [forebrain development] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031295 [T cell costimulation] GO:0031648 [protein destabilization] GO:0031667 [response to nutrient levels] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032148 [activation of protein kinase B activity] GO:0032403 [protein complex binding] GO:0032463 [negative regulation of protein homooligomerization] GO:0032587 [ruffle membrane] GO:0032869 [cellular response to insulin stimulus] GO:0033146 [regulation of intracellular estrogen receptor signaling pathway] GO:0033625 [positive regulation of integrin activation] GO:0034332 [adherens junction organization] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0034614 [cellular response to reactive oxygen species] GO:0035556 [intracellular signal transduction] GO:0036035 [osteoclast development] GO:0036120 [cellular response to platelet-derived growth factor stimulus] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0042493 [response to drug] GO:0042542 [response to hydrogen peroxide] GO:0043005 [neuron projection] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043114 [regulation of vascular permeability] GO:0043149 [stress fiber assembly] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043393 [regulation of protein binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0044325 [ion channel binding] GO:0045056 [transcytosis] GO:0045087 [innate immune response] GO:0045124 [regulation of bone resorption] GO:0045453 [bone resorption] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045785 [positive regulation of cell adhesion] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046628 [positive regulation of insulin receptor signaling pathway] GO:0046777 [protein autophosphorylation] GO:0046875 [ephrin receptor binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0048477 [oogenesis] GO:0050715 [positive regulation of cytokine secretion] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050839 [cell adhesion molecule binding] GO:0050847 [progesterone receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051219 [phosphoprotein binding] GO:0051222 [positive regulation of protein transport] GO:0051385 [response to mineralocorticoid] GO:0051427 [hormone receptor binding] GO:0051602 [response to electrical stimulus] GO:0051726 [regulation of cell cycle] GO:0051895 [negative regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051902 [negative regulation of mitochondrial depolarization] GO:0060065 [uterus development] GO:0060444 [branching involved in mammary gland duct morphogenesis] GO:0060491 [regulation of cell projection assembly] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070542 [response to fatty acid] GO:0070555 [response to interleukin-1] GO:0070851 [growth factor receptor binding] GO:0071222 [cellular response to lipopolysaccharide] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071393 [cellular response to progesterone stimulus] GO:0071398 [cellular response to fatty acid] GO:0071456 [cellular response to hypoxia] GO:0071498 [cellular response to fluid shear stress] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:0071801 [regulation of podosome assembly] GO:0071803 [positive regulation of podosome assembly] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0086098 [angiotensin-activated signaling pathway involved in heart process] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0097110 [scaffold protein binding] GO:1902533 [positive regulation of intracellular signal transduction] GO:2000394 [positive regulation of lamellipodium morphogenesis] GO:2000573 [positive regulation of DNA biosynthetic process] GO:2000641 [regulation of early endosome to late endosome transport] GO:2000811 [negative regulation of anoikis] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001286 [regulation of caveolin-mediated endocytosis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005102 [receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010632 [regulation of epithelial cell migration] GO:0010634 [positive regulation of epithelial cell migration] GO:0016032 [viral process] GO:0016301 [kinase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0020037 [heme binding] GO:0022407 [regulation of cell-cell adhesion] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031295 [T cell costimulation] GO:0032463 [negative regulation of protein homooligomerization] GO:0033625 [positive regulation of integrin activation] GO:0035556 [intracellular signal transduction] GO:0036035 [osteoclast development] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0043066 [negative regulation of apoptotic process] GO:0043114 [regulation of vascular permeability] GO:0043149 [stress fiber assembly] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044325 [ion channel binding] GO:0045087 [innate immune response] GO:0045124 [regulation of bone resorption] GO:0045453 [bone resorption] GO:0046777 [protein autophosphorylation] GO:0046875 [ephrin receptor binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050847 [progesterone receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051219 [phosphoprotein binding] GO:0051427 [hormone receptor binding] GO:0051726 [regulation of cell cycle] GO:0051895 [negative regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051902 [negative regulation of mitochondrial depolarization] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] GO:0070555 [response to interleukin-1] GO:0070851 [growth factor receptor binding] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071393 [cellular response to progesterone stimulus] GO:0071801 [regulation of podosome assembly] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0086098 [angiotensin-activated signaling pathway involved in heart process] GO:0097110 [scaffold protein binding] GO:2000394 [positive regulation of lamellipodium morphogenesis] GO:2000641 [regulation of early endosome to late endosome transport] GO:2000811 [negative regulation of anoikis] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001286 [regulation of caveolin-mediated endocytosis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005102 [receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010632 [regulation of epithelial cell migration] GO:0010634 [positive regulation of epithelial cell migration] GO:0016032 [viral process] GO:0016301 [kinase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0020037 [heme binding] GO:0022407 [regulation of cell-cell adhesion] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031295 [T cell costimulation] GO:0032463 [negative regulation of protein homooligomerization] GO:0033625 [positive regulation of integrin activation] GO:0035556 [intracellular signal transduction] GO:0036035 [osteoclast development] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0043066 [negative regulation of apoptotic process] GO:0043114 [regulation of vascular permeability] GO:0043149 [stress fiber assembly] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044325 [ion channel binding] GO:0045087 [innate immune response] GO:0045124 [regulation of bone resorption] GO:0045453 [bone resorption] GO:0046777 [protein autophosphorylation] GO:0046875 [ephrin receptor binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050847 [progesterone receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051219 [phosphoprotein binding] GO:0051427 [hormone receptor binding] GO:0051726 [regulation of cell cycle] GO:0051895 [negative regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051902 [negative regulation of mitochondrial depolarization] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] GO:0070555 [response to interleukin-1] GO:0070851 [growth factor receptor binding] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071393 [cellular response to progesterone stimulus] GO:0071801 [regulation of podosome assembly] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0086098 [angiotensin-activated signaling pathway involved in heart process] GO:0097110 [scaffold protein binding] GO:2000394 [positive regulation of lamellipodium morphogenesis] GO:2000641 [regulation of early endosome to late endosome transport] GO:2000811 [negative regulation of anoikis] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001286 [regulation of caveolin-mediated endocytosis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005102 [receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010632 [regulation of epithelial cell migration] GO:0010634 [positive regulation of epithelial cell migration] GO:0016032 [viral process] GO:0016301 [kinase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0020037 [heme binding] GO:0022407 [regulation of cell-cell adhesion] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031295 [T cell costimulation] GO:0032463 [negative regulation of protein homooligomerization] GO:0033625 [positive regulation of integrin activation] GO:0035556 [intracellular signal transduction] GO:0036035 [osteoclast development] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0043066 [negative regulation of apoptotic process] GO:0043114 [regulation of vascular permeability] GO:0043149 [stress fiber assembly] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044325 [ion channel binding] GO:0045087 [innate immune response] GO:0045124 [regulation of bone resorption] GO:0045453 [bone resorption] GO:0046777 [protein autophosphorylation] GO:0046875 [ephrin receptor binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050847 [progesterone receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051219 [phosphoprotein binding] GO:0051427 [hormone receptor binding] GO:0051726 [regulation of cell cycle] GO:0051895 [negative regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051902 [negative regulation of mitochondrial depolarization] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] GO:0070555 [response to interleukin-1] GO:0070851 [growth factor receptor binding] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071393 [cellular response to progesterone stimulus] GO:0071801 [regulation of podosome assembly] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0086098 [angiotensin-activated signaling pathway involved in heart process] GO:0097110 [scaffold protein binding] GO:2000394 [positive regulation of lamellipodium morphogenesis] GO:2000641 [regulation of early endosome to late endosome transport] GO:2000811 [negative regulation of anoikis] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001286 [regulation of caveolin-mediated endocytosis]