Expression of ADAM32 in cancer - Summary - The Human Protein Atlas

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ADAM32

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADAM32
Gene description	ADAM metallopeptidase domain 32
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (U-2 OS)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in seminiferous ducts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA044156
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044156

GENE INFORMATION
Gene name	ADAM32
Synonyms
Description	ADAM metallopeptidase domain 32 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. This gene is predominantly expressed in the testis. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Chromosome	8
Cytoband	p11.22
Chromosome location (bp)	39106990 - 39284911
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197140 (version 83.38)
Entrez gene	203102
UniProt	Q8TC27 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TC27
Antibodypedia	ADAM32 antibodies

PROTEIN BROWSER

ADAM32-001	ADAM32-005	ADAM32-006	ADAM32-008	ADAM32-009	ADAM32-010	ADAM32-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAM32-001 ENSP00000369238 ENST00000379907	Q8TC27 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 32 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	787 aa 87.9 kDa	Yes	1
ADAM32-005 ENSP00000429422 ENST00000519315	E7ER82 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 32 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	629 aa 71 kDa	Yes	1
ADAM32-006 ENSP00000427735 ENST00000523400	E5RGK7 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 32 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	173 aa 20 kDa	No	0
ADAM32-008 ENSP00000405978 ENST00000437682	E7EPX8 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 32 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	688 aa 76.7 kDa	No	1
ADAM32-009 ENSP00000431050 ENST00000521741	E5RJY7 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 32 Show all	Predicted intracellular proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	53 aa 6 kDa	No	0
ADAM32-010 ENSP00000382727 ENST00000399831	E3W988 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 32 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	155 aa 17.9 kDa	Yes	0
ADAM32-011 ENSP00000429066 ENST00000522506	E5RJE6 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 32 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	184 aa 21.3 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.