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ABCB8

GENERAL INFORMATION

Gene name

 ABCB8

Gene description

 ATP-binding cassette, sub-family B (MDR/TAP), member 8

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and nuclear expression in several different tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA045187
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable), renal cancer (favourable) and head and neck cancer (favourable).
Pancreatic cancer p<0.001
Renal cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045187

GENE INFORMATION

Gene name

 ABCB8 (HGNC Symbol)

Synonyms

 EST328128, M-ABC1, MABC1

Description

 ATP-binding cassette, sub-family B (MDR/TAP), member 8 (HGNC Symbol)

Entrez gene summary

 This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

 7

Cytoband

 q36.1

Chromosome location (bp)

 151028422 - 151047782

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197150 (version 83.38)

Entrez gene

 11194

UniProt

 Q9NUT2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NUT2

Antibodypedia

 ABCB8 antibodies

PROTEIN BROWSER
ABCB8-003
ABCB8-005
ABCB8-008
ABCB8-009
ABCB8-010
ABCB8-012
ABCB8-023
ABCB8-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABCB8-003
ENSP00000297504
ENST00000297504
Q9NUT2 [Direct mapping]
ATP-binding cassette sub-family B member 8, mitochondrial
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Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0005740 [mitochondrial envelope]
GO:0005743 [mitochondrial inner membrane]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0043190 [ATP-binding cassette (ABC) transporter complex]
GO:0055085 [transmembrane transport]
Show all
 735 aa
80 kDa 		No 7
ABCB8-005
ENSP00000351717
ENST00000358849
Q9NUT2 [Direct mapping]
ATP-binding cassette sub-family B member 8, mitochondrial
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0005740 [mitochondrial envelope]
GO:0005743 [mitochondrial inner membrane]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0043190 [ATP-binding cassette (ABC) transporter complex]
GO:0055085 [transmembrane transport]
Show all
 718 aa
78.1 kDa 		No 7
ABCB8-008
ENSP00000418271
ENST00000498578
Q9NUT2 [Direct mapping]
ATP-binding cassette sub-family B member 8, mitochondrial
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0005740 [mitochondrial envelope]
GO:0005743 [mitochondrial inner membrane]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0043190 [ATP-binding cassette (ABC) transporter complex]
GO:0055085 [transmembrane transport]
Show all
 693 aa
75.3 kDa 		No 5
ABCB8-009
ENSP00000419891
ENST00000477719
C9JYI3 [Direct mapping]
ATP-binding cassette sub-family B member 8, mitochondrial
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0006810 [transport]
GO:0016021 [integral component of membrane]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
 409 aa
44.7 kDa 		No 5
ABCB8-010
ENSP00000419558
ENST00000477092
C9JTY4 [Direct mapping]
ATP-binding cassette sub-family B member 8, mitochondrial; ATP-binding cassette, sub-family B (MDR/TAP), member 8, isoform CRA_c
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0006810 [transport]
GO:0016021 [integral component of membrane]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
 431 aa
47.1 kDa 		No 5
ABCB8-012
ENSP00000417563
ENST00000461373
C9JA03 [Direct mapping]
ATP-binding cassette sub-family B member 8, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
 148 aa
16.3 kDa 		No 0
ABCB8-023
ENSP00000420162
ENST00000491920
H7C5K9 [Direct mapping]
ATP-binding cassette sub-family B member 8, mitochondrial
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006810 [transport]
GO:0016021 [integral component of membrane]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
 140 aa
14.9 kDa 		No 1
ABCB8-201
ENSP00000438776
ENST00000542328
Q9NUT2 [Direct mapping]
ATP-binding cassette sub-family B member 8, mitochondrial
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0005740 [mitochondrial envelope]
GO:0005743 [mitochondrial inner membrane]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0043190 [ATP-binding cassette (ABC) transporter complex]
GO:0055085 [transmembrane transport]
Show all
 630 aa
68.1 kDa 		Yes 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.