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NEK5

GENERAL INFORMATION

Gene name

 NEK5

Gene description

 NIMA-related kinase 5

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (T-47d)
HPA (normal tissue):Group enriched (fallopian tube, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Expression in cilia in fallopian tube and cells in seminiferous ducts of testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA035565 , HPA041399
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA035565
HPA041399

GENE INFORMATION

Gene name

 NEK5

Synonyms

Description

 NIMA-related kinase 5 (HGNC Symbol)

Entrez gene summary

Chromosome

 13

Cytoband

 q14.3

Chromosome location (bp)

 52033611 - 52129078

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197168 (version 83.38)

Entrez gene

 341676

UniProt

 Q6P3R8 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q6P3R8

Antibodypedia

 NEK5 antibodies

PROTEIN BROWSER
NEK5-001
NEK5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NEK5-001
ENSP00000347767
ENST00000355568
Q6P3R8 [Direct mapping]
Serine/threonine-protein kinase Nek5
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0046872 [metal ion binding]
GO:0051155 [positive regulation of striated muscle cell differentiation]
GO:2001056 [positive regulation of cysteine-type endopeptidase activity]
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 708 aa
81.4 kDa 		No 0
NEK5-201
ENSP00000477810
ENST00000617045
Q6P3R8 [Direct mapping]
Serine/threonine-protein kinase Nek5
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0046872 [metal ion binding]
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 708 aa
81.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.