Expression of ZSCAN5B in cancer - Summary

GENERAL INFORMATION
Gene name	ZSCAN5B
Gene description	Zinc finger and SCAN domain containing 5B
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in selected cells including Leydig cells and glandular cells in the intestine.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 3 antibodies. HPA043123 , HPA046836 , HPA059494
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

STAINING SUMMARY

HPA043123	HPA046836	HPA059494

GENE INFORMATION
Gene name	ZSCAN5B (HGNC Symbol)
Synonyms	ZNF371, ZNF495B
Description	Zinc finger and SCAN domain containing 5B (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.43
Chromosome location (bp)	56189570 - 56197920
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197213 (version 83.38)
Entrez gene	342933
UniProt	A6NJL1 (UniProt - Inferred from homology)
neXtProt	NX_A6NJL1
Antibodypedia	ZSCAN5B antibodies

PROTEIN BROWSER

ZSCAN5B-001	ZSCAN5B-002	ZSCAN5B-003	ZSCAN5B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZSCAN5B-001 ENSP00000466072 ENST00000586855	A6NJL1 [Direct mapping] Zinc finger and SCAN domain-containing protein 5B Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	495 aa 55.8 kDa	No	0
ZSCAN5B-002 ENSP00000465118 ENST00000589938	K7EJD1 [Direct mapping] Zinc finger and SCAN domain-containing protein 5B Show all	Predicted intracellular proteins Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	169 aa 19.3 kDa	No	0
ZSCAN5B-003 ENSP00000468660 ENST00000587032	K7ESD3 [Direct mapping] Zinc finger and SCAN domain-containing protein 5B Show all	Predicted intracellular proteins Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	137 aa 15.8 kDa	No	0
ZSCAN5B-201 ENSP00000351883 ENST00000358992	A6NJL1 [Direct mapping] Zinc finger and SCAN domain-containing protein 5B Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	495 aa 55.8 kDa	No	0