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C1D

GENERAL INFORMATION

Gene name

 C1D

Gene description

 C1D nuclear receptor corepressor

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear/nucleolar expression accompanied by cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA037413 , HPA037588
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037413
HPA037588

GENE INFORMATION

Gene name

 C1D (HGNC Symbol)

Synonyms

 LRP1, Rrp47, SUN-CoR, SUNCOR

Description

 C1D nuclear receptor corepressor (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]

Chromosome

 2

Cytoband

 p14

Chromosome location (bp)

 68041130 - 68110948

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197223 (version 83.38)

Entrez gene

 10438

UniProt

 Q13901 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13901

Antibodypedia

 C1D antibodies

PROTEIN BROWSER
C1D-001
C1D-002
C1D-006
C1D-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
C1D-001
ENSP00000348107
ENST00000355848
Q13901 [Direct mapping]
Nuclear nucleic acid-binding protein C1D
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000176 [nuclear exosome (RNase complex)]
GO:0000460 [maturation of 5.8S rRNA]
GO:0003677 [DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0017053 [transcriptional repressor complex]
GO:0045892 [negative regulation of transcription, DNA-templated]
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 141 aa
16 kDa 		No 0
C1D-002
ENSP00000384304
ENST00000407324
J3KPZ4 [Direct mapping]
Nuclear nucleic acid-binding protein C1D
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
GO:0005730 [nucleolus]
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 180 aa
20.1 kDa 		No 0
C1D-006
ENSP00000386468
ENST00000410067
Q13901 [Direct mapping]
Nuclear nucleic acid-binding protein C1D
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000460 [maturation of 5.8S rRNA]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
Show all
 141 aa
16 kDa 		No 0
C1D-007
ENSP00000386779
ENST00000409302
Q13901 [Direct mapping]
Nuclear nucleic acid-binding protein C1D
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000460 [maturation of 5.8S rRNA]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
Show all
 141 aa
16 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.