Expression of TBC1D9B in cancer - Summary - The Human Protein Atlas

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TBC1D9B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TBC1D9B
Gene description	TBC1 domain family, member 9B (with GRAM domain)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA038350
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable).
Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038350

GENE INFORMATION
Gene name	TBC1D9B (HGNC Symbol)
Synonyms	KIAA0676
Description	TBC1 domain family, member 9B (with GRAM domain) (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q35.3
Chromosome location (bp)	179862066 - 179907859
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197226 (version 83.38)
Entrez gene	23061
UniProt	Q66K14 (UniProt - Evidence at protein level)
neXtProt	NX_Q66K14
Antibodypedia	TBC1D9B antibodies

PROTEIN BROWSER

TBC1D9B-001	TBC1D9B-002	TBC1D9B-005	TBC1D9B-009	TBC1D9B-019	TBC1D9B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TBC1D9B-001 ENSP00000349291 ENST00000356834	Q66K14 [Direct mapping] TBC1 domain family member 9B Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0043547 [positive regulation of GTPase activity] Show all	1250 aa 140.5 kDa	No	0
TBC1D9B-002 ENSP00000347375 ENST00000355235	Q66K14 [Direct mapping] TBC1 domain family member 9B Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0043547 [positive regulation of GTPase activity] Show all	1233 aa 138.7 kDa	No	0
TBC1D9B-005 ENSP00000430293 ENST00000519746	G3V133 [Direct mapping] KIAA0676 protein, isoform CRA_d; TBC1 domain family member 9B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	409 aa 45.2 kDa	No	0
TBC1D9B-009 ENSP00000428724 ENST00000524222	H0YB58 [Direct mapping] TBC1 domain family member 9B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		65 aa 7.5 kDa	No	0
TBC1D9B-019 ENSP00000428441 ENST00000522472	H0YB08 [Direct mapping] TBC1 domain family member 9B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		166 aa 19 kDa	No	0
TBC1D9B-201 ENSP00000486765 ENST00000630103	E5RIN2 [Direct mapping] TBC1 domain family member 9B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		100 aa 11.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.