Tissue expression of IL27 - Summary - The Human Protein Atlas

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IL27

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	IL27
Gene description	Interleukin 27
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (liver)
GTEx:	Tissue enriched (liver)
FANTOM5:	Not detected

Protein evidence

Evidence at protein level

Protein expression

Membranous and cytoplasmic expression in endothelial cells, bone marrow and subsets of immune cells in peripheral tissues, including gastrointestinal tract.

DATA RELIABILITY
Data reliability description	Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 1 antibody. CAB024722
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (liver)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Not detected

GENE INFORMATION
Gene name	IL27 (HGNC Symbol)
Synonyms	IL-27, IL-27A, IL27A, IL27p28, IL30, MGC71873, p28
Description	Interleukin 27 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband
Chromosome location (bp)	28499362 - 28512051
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197272 (version 83.38)
Entrez gene	246778
UniProt	Q8NEV9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NEV9
Antibodypedia	IL27 antibodies

PROTEIN BROWSER

IL27-001	IL27-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL27-001 ENSP00000349365 ENST00000356897	Q8NEV9 [Direct mapping] Interleukin-27 subunit alpha Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005102 [receptor binding] GO:0005125 [cytokine activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0006954 [inflammatory response] GO:0009617 [response to bacterium] GO:0042129 [regulation of T cell proliferation] GO:0045078 [positive regulation of interferon-gamma biosynthetic process] GO:0045087 [innate immune response] GO:0045523 [interleukin-27 receptor binding] GO:0045625 [regulation of T-helper 1 cell differentiation] GO:0050688 [regulation of defense response to virus] Show all	243 aa 27.5 kDa	Yes	0
IL27-002 ENSP00000455990 ENST00000568075	H3BQY2 [Direct mapping] Interleukin-27 subunit alpha Show all	Predicted intracellular proteins Show all		24 aa 3.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.