Expression of MRPL21 in cancer - Summary

GENERAL INFORMATION
Gene name	MRPL21
Gene description	Mitochondrial ribosomal protein L21
Protein class	Predicted intracellular proteins Predicted secreted proteins Ribosomal proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic and cases of membranous expression in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA051657
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable).
Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA051657

GENE INFORMATION
Gene name	MRPL21
Synonyms
Description	Mitochondrial ribosomal protein L21 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q13.3
Chromosome location (bp)	68891276 - 68903835
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197345 (version 83.38)
Entrez gene	219927
UniProt	Q7Z2W9 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z2W9
Antibodypedia	MRPL21 antibodies

PROTEIN BROWSER

MRPL21-001	MRPL21-005	MRPL21-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPL21-001 ENSP00000354580 ENST00000362034	Q7Z2W9 [Direct mapping] 39S ribosomal protein L21, mitochondrial Show all	Ribosomal proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0005840 [ribosome] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	205 aa 22.8 kDa	Yes	0
MRPL21-005 ENSP00000457859 ENST00000567045	H3BUY0 [Direct mapping] 39S ribosomal protein L21, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005840 [ribosome] Show all	195 aa 21.5 kDa	No	0
MRPL21-008 ENSP00000389400 ENST00000450904	Q7Z2W9 [Direct mapping] 39S ribosomal protein L21, mitochondrial A0A024R5G7 [Target identity:100%; Query identity:100%] Mitochondrial ribosomal protein L21, isoform CRA_a Show all	Ribosomal proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0005840 [ribosome] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	120 aa 13.7 kDa	No	0