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ADARB1

GENERAL INFORMATION

Gene name

 ADARB1

Gene description

 Adenosine deaminase, RNA-specific, B1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Sub cellular location is contradicted by external data.

Reliability score

 Uncertain based on 1 antibody.
HPA018277
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable) and renal cancer (unfavourable).
Colorectal cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA018277

GENE INFORMATION

Gene name

 ADARB1 (HGNC Symbol)

Synonyms

 ADAR2, ADAR2a, ADAR2a-L1, ADAR2a-L2, ADAR2a-L3, ADAR2b, ADAR2c, ADAR2d, ADAR2g, DRABA2, DRADA2, hRED1, RED1

Description

 Adenosine deaminase, RNA-specific, B1 (HGNC Symbol)

Entrez gene summary

 This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q22.3

Chromosome location (bp)

 45073853 - 45226560

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197381 (version 83.38)

Entrez gene

 104

UniProt

 P78563 (UniProt - Evidence at protein level)

neXtProt

 NX_P78563

Antibodypedia

 ADARB1 antibodies

PROTEIN BROWSER
ADARB1-004
ADARB1-005
ADARB1-008
ADARB1-011
ADARB1-201
ADARB1-202
ADARB1-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADARB1-004
ENSP00000353920
ENST00000360697
P78563 [Direct mapping]
Double-stranded RNA-specific editase 1
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Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0003726 [double-stranded RNA adenosine deaminase activity]
GO:0003729 [mRNA binding]
GO:0004000 [adenosine deaminase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006382 [adenosine to inosine editing]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0016553 [base conversion or substitution editing]
GO:0016556 [mRNA modification]
GO:0030336 [negative regulation of cell migration]
GO:0044387 [negative regulation of protein kinase activity by regulation of protein phosphorylation]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0051607 [defense response to virus]
GO:0051726 [regulation of cell cycle]
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 741 aa
80.8 kDa 		No 0
ADARB1-005
ENSP00000374513
ENST00000389863
P78563 [Direct mapping]
Double-stranded RNA-specific editase 1
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Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0003726 [double-stranded RNA adenosine deaminase activity]
GO:0003729 [mRNA binding]
GO:0004000 [adenosine deaminase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006382 [adenosine to inosine editing]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0016553 [base conversion or substitution editing]
GO:0016556 [mRNA modification]
GO:0030336 [negative regulation of cell migration]
GO:0044387 [negative regulation of protein kinase activity by regulation of protein phosphorylation]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0051607 [defense response to virus]
GO:0051726 [regulation of cell cycle]
Show all
 714 aa
77.8 kDa 		No 0
ADARB1-008
ENSP00000387480
ENST00000449478
A0A0A0MSG8 [Direct mapping]
Double-stranded RNA-specific editase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 141 aa
15.1 kDa 		No 0
ADARB1-011
ENSP00000015877
ENST00000348831
P78563 [Direct mapping]
Double-stranded RNA-specific editase 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0003726 [double-stranded RNA adenosine deaminase activity]
GO:0003729 [mRNA binding]
GO:0004000 [adenosine deaminase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006382 [adenosine to inosine editing]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0016553 [base conversion or substitution editing]
GO:0016556 [mRNA modification]
GO:0030336 [negative regulation of cell migration]
GO:0044387 [negative regulation of protein kinase activity by regulation of protein phosphorylation]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0051607 [defense response to virus]
GO:0051726 [regulation of cell cycle]
Show all
 701 aa
76.6 kDa 		No 0
ADARB1-201
ENSP00000414600
ENST00000437626
P78563 [Direct mapping]
Double-stranded RNA-specific editase 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0003726 [double-stranded RNA adenosine deaminase activity]
GO:0003729 [mRNA binding]
GO:0004000 [adenosine deaminase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006382 [adenosine to inosine editing]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0016553 [base conversion or substitution editing]
GO:0016556 [mRNA modification]
GO:0030336 [negative regulation of cell migration]
GO:0044387 [negative regulation of protein kinase activity by regulation of protein phosphorylation]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0051607 [defense response to virus]
GO:0051726 [regulation of cell cycle]
Show all
 741 aa
80.8 kDa 		No 0
ADARB1-202
ENSP00000478160
ENST00000611195
Q8TCX7 [Direct mapping]
Double-stranded RNA-specific editase 1; HCG2008433
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 52 aa
6 kDa 		No 0
ADARB1-203
ENSP00000486475
ENST00000629643
P78563 [Direct mapping]
Double-stranded RNA-specific editase 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0003726 [double-stranded RNA adenosine deaminase activity]
GO:0003729 [mRNA binding]
GO:0004000 [adenosine deaminase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006382 [adenosine to inosine editing]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0016553 [base conversion or substitution editing]
GO:0016556 [mRNA modification]
GO:0030336 [negative regulation of cell migration]
GO:0044387 [negative regulation of protein kinase activity by regulation of protein phosphorylation]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0051607 [defense response to virus]
GO:0051726 [regulation of cell cycle]
Show all
 729 aa
80 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.