Expression of OPALIN in cancer - Summary - The Human Protein Atlas

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OPALIN

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	OPALIN
Gene description	Oligodendrocytic myelin paranodal and inner loop protein
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded. External characterization data supports antibody staining.
Reliability score	Supported based on 1 antibody. HPA014372
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014372

GENE INFORMATION
Gene name	OPALIN (HGNC Symbol)
Synonyms	HTMP10, TMEM10, TMP10
Description	Oligodendrocytic myelin paranodal and inner loop protein (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	q24.1
Chromosome location (bp)	96343216 - 96359365
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197430 (version 83.38)
Entrez gene	93377
UniProt	Q96PE5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96PE5
Antibodypedia	OPALIN antibodies

PROTEIN BROWSER

OPALIN-001	OPALIN-201	OPALIN-202	OPALIN-203	OPALIN-204	OPALIN-205

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OPALIN-001 ENSP00000360214 ENST00000371172	Q96PE5 [Direct mapping] Opalin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0044291 [cell-cell contact zone] Show all	141 aa 15.7 kDa	No	1
OPALIN-201 ENSP00000377448 ENST00000393870	A0A0A0MS47 [Direct mapping] Opalin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	129 aa 14.4 kDa	No	0
OPALIN-202 ENSP00000377449 ENST00000393871	Q96PE5 [Direct mapping] Opalin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	118 aa 13.3 kDa	No	0
OPALIN-203 ENSP00000398025 ENST00000419479	Q96PE5 [Direct mapping] Opalin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	130 aa 14.6 kDa	No	0
OPALIN-204 ENSP00000445125 ENST00000536387	A0A0A0MTN4 [Direct mapping] Opalin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		79 aa 9.3 kDa	No	0
OPALIN-205 ENSP00000484599 ENST00000611913	Q96PE5 [Direct mapping] Opalin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	131 aa 14.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.