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GSTK1

GENERAL INFORMATION

Gene name

 GSTK1

Gene description

 Glutathione S-transferase kappa 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous granular cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA006311 , HPA022904
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and breast cancer (favourable).
Renal cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006311
HPA022904

GENE INFORMATION

Gene name

 GSTK1 (HGNC Symbol)

Synonyms

 GST13

Description

 Glutathione S-transferase kappa 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

Chromosome

 7

Cytoband

 q34

Chromosome location (bp)

 143244093 - 143270854

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197448 (version 83.38)

Entrez gene

 373156

UniProt

 Q9Y2Q3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2Q3

Antibodypedia

 GSTK1 antibodies

PROTEIN BROWSER
GSTK1-001
GSTK1-004
GSTK1-005
GSTK1-007
GSTK1-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GSTK1-001
ENSP00000351181
ENST00000358406
Q9Y2Q3 [Direct mapping]
Glutathione S-transferase kappa 1
Q6FII1 [Target identity:100%; Query identity:100%]
Glutathione S-transferase kappa 1; Glutathione S-transferase kappa 1, isoform CRA_d; LOC51064 protein; cDNA FLJ78056
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004364 [glutathione transferase activity]
GO:0004602 [glutathione peroxidase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005759 [mitochondrial matrix]
GO:0005777 [peroxisome]
GO:0006805 [xenobiotic metabolic process]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0016020 [membrane]
GO:0030855 [epithelial cell differentiation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:1901687 [glutathione derivative biosynthetic process]
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 226 aa
25.5 kDa 		No 0
GSTK1-004
ENSP00000431049
ENST00000479303
Q9Y2Q3 [Direct mapping]
Glutathione S-transferase kappa 1
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004364 [glutathione transferase activity]
GO:0004602 [glutathione peroxidase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005777 [peroxisome]
GO:0006749 [glutathione metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0016020 [membrane]
GO:0030855 [epithelial cell differentiation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:1901687 [glutathione derivative biosynthetic process]
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 282 aa
31.6 kDa 		No 0
GSTK1-005
ENSP00000408341
ENST00000436038
C9JNT3 [Direct mapping]
Glutathione S-transferase kappa 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0055114 [oxidation-reduction process]
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 118 aa
13.7 kDa 		No 0
GSTK1-007
ENSP00000386944
ENST00000409500
Q9Y2Q3 [Direct mapping]
Glutathione S-transferase kappa 1
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004364 [glutathione transferase activity]
GO:0004602 [glutathione peroxidase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005759 [mitochondrial matrix]
GO:0005777 [peroxisome]
GO:0006805 [xenobiotic metabolic process]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0016020 [membrane]
GO:0030855 [epithelial cell differentiation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:1901687 [glutathione derivative biosynthetic process]
Show all
 214 aa
24.2 kDa 		No 0
GSTK1-009
ENSP00000415813
ENST00000443571
Q9Y2Q3 [Direct mapping]
Glutathione S-transferase kappa 1
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004364 [glutathione transferase activity]
GO:0004602 [glutathione peroxidase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005759 [mitochondrial matrix]
GO:0005777 [peroxisome]
GO:0006805 [xenobiotic metabolic process]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0016020 [membrane]
GO:0030855 [epithelial cell differentiation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:1901687 [glutathione derivative biosynthetic process]
Show all
 183 aa
20.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.