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Malignant melanoma and skin cancers showed strong cytoplasmic positivity. Several renal cancers showed strong cytoplasmic and membranous staining. Malignant lymphomas were generally negative. Remaining malignant cells generally showed weak to moderate cytoplasmic immunoreactivity.
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
P04085 [Direct mapping] Platelet-derived growth factor subunit A
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P04085 [Direct mapping] Platelet-derived growth factor subunit A
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001525 [angiogenesis] GO:0001666 [response to hypoxia] GO:0001775 [cell activation] GO:0001942 [hair follicle development] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002576 [platelet degranulation] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0005902 [microvillus] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007267 [cell-cell signaling] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008083 [growth factor activity] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009611 [response to wounding] GO:0009887 [organ morphogenesis] GO:0009986 [cell surface] GO:0010033 [response to organic substance] GO:0010035 [response to inorganic substance] GO:0010512 [negative regulation of phosphatidylinositol biosynthetic process] GO:0010544 [negative regulation of platelet activation] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014910 [regulation of smooth muscle cell migration] GO:0016020 [membrane] GO:0030031 [cell projection assembly] GO:0030036 [actin cytoskeleton organization] GO:0030168 [platelet activation] GO:0030198 [extracellular matrix organization] GO:0030335 [positive regulation of cell migration] GO:0031093 [platelet alpha granule lumen] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032355 [response to estradiol] GO:0032526 [response to retinoic acid] GO:0032956 [regulation of actin cytoskeleton organization] GO:0035793 [positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042060 [wound healing] GO:0042493 [response to drug] GO:0042803 [protein homodimerization activity] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0043588 [skin development] GO:0045087 [innate immune response] GO:0045740 [positive regulation of DNA replication] GO:0046982 [protein heterodimerization activity] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048286 [lung alveolus development] GO:0048407 [platelet-derived growth factor binding] GO:0048565 [digestive tract development] GO:0048839 [inner ear development] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050919 [negative chemotaxis] GO:0051781 [positive regulation of cell division] GO:0051897 [positive regulation of protein kinase B signaling] GO:0060348 [bone development] GO:0060683 [regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:1990401 [embryonic lung development]