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ATG7

GENERAL INFORMATION

Gene name

 ATG7

Gene description

 Autophagy related 7

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA007639 , CAB018771
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (favourable) and colorectal cancer (favourable).
Liver cancer p<0.001
Renal cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA007639
CAB018771

GENE INFORMATION

Gene name

 ATG7 (HGNC Symbol)

Synonyms

 APG7L, DKFZp434N0735, GSA7

Description

 Autophagy related 7 (HGNC Symbol)

Entrez gene summary

 This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Chromosome

 3

Cytoband

 p25.3

Chromosome location (bp)

 11272309 - 11557665

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197548 (version 83.38)

Entrez gene

 10533

UniProt

 O95352 (UniProt - Evidence at protein level)

neXtProt

 NX_O95352

Antibodypedia

 ATG7 antibodies

PROTEIN BROWSER
«
ATG7-001
ATG7-002
ATG7-004
ATG7-005
ATG7-006
ATG7-007
ATG7-008
ATG7-009
ATG7-010
ATG7-020
ATG7-021
ATG7-022
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATG7-001
ENSP00000346437
ENST00000354449
O95352 [Direct mapping]
Ubiquitin-like modifier-activating enzyme ATG7
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000407 [pre-autophagosomal structure]
GO:0001889 [liver development]
GO:0004839 [ubiquitin activating enzyme activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005930 [axoneme]
GO:0006464 [cellular protein modification process]
GO:0006497 [protein lipidation]
GO:0006501 [C-terminal protein lipidation]
GO:0006520 [cellular amino acid metabolic process]
GO:0006914 [autophagy]
GO:0006995 [cellular response to nitrogen starvation]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0007628 [adult walking behavior]
GO:0008134 [transcription factor binding]
GO:0008641 [small protein activating enzyme activity]
GO:0009267 [cellular response to starvation]
GO:0009791 [post-embryonic development]
GO:0010508 [positive regulation of autophagy]
GO:0015031 [protein transport]
GO:0016236 [macroautophagy]
GO:0016239 [positive regulation of macroautophagy]
GO:0016567 [protein ubiquitination]
GO:0019778 [Atg12 activating enzyme activity]
GO:0019779 [Atg8 activating enzyme activity]
GO:0021680 [cerebellar Purkinje cell layer development]
GO:0021860 [pyramidal neuron development]
GO:0021955 [central nervous system neuron axonogenesis]
GO:0021987 [cerebral cortex development]
GO:0030163 [protein catabolic process]
GO:0031175 [neuron projection development]
GO:0031396 [regulation of protein ubiquitination]
GO:0031401 [positive regulation of protein modification process]
GO:0032446 [protein modification by small protein conjugation]
GO:0034727 [piecemeal microautophagy of nucleus]
GO:0039521 [suppression by virus of host autophagy]
GO:0039689 [negative stranded viral RNA replication]
GO:0042594 [response to starvation]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0044805 [late nucleophagy]
GO:0045732 [positive regulation of protein catabolic process]
GO:0050877 [neurological system process]
GO:0051607 [defense response to virus]
GO:0055013 [cardiac muscle cell development]
GO:0061024 [membrane organization]
GO:0061025 [membrane fusion]
GO:0070257 [positive regulation of mucus secretion]
GO:0071455 [cellular response to hyperoxia]
GO:1903146 [regulation of mitophagy]
GO:2000619 [negative regulation of histone H4-K16 acetylation]
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 703 aa
78 kDa 		No 0
ATG7-002
ENSP00000412580
ENST00000446450
O95352 [Direct mapping]
Ubiquitin-like modifier-activating enzyme ATG7
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000407 [pre-autophagosomal structure]
GO:0004839 [ubiquitin activating enzyme activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005930 [axoneme]
GO:0006464 [cellular protein modification process]
GO:0006497 [protein lipidation]
GO:0006501 [C-terminal protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0008134 [transcription factor binding]
GO:0008641 [small protein activating enzyme activity]
GO:0009267 [cellular response to starvation]
GO:0010508 [positive regulation of autophagy]
GO:0015031 [protein transport]
GO:0016236 [macroautophagy]
GO:0016239 [positive regulation of macroautophagy]
GO:0016567 [protein ubiquitination]
GO:0019778 [Atg12 activating enzyme activity]
GO:0019779 [Atg8 activating enzyme activity]
GO:0031401 [positive regulation of protein modification process]
GO:0034727 [piecemeal microautophagy of nucleus]
GO:0039521 [suppression by virus of host autophagy]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0044805 [late nucleophagy]
GO:0045732 [positive regulation of protein catabolic process]
GO:0051607 [defense response to virus]
GO:0061025 [membrane fusion]
GO:0071455 [cellular response to hyperoxia]
GO:1903146 [regulation of mitophagy]
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 623 aa
68.6 kDa 		No 0
ATG7-004
ENSP00000347042
ENST00000354956
O95352 [Direct mapping]
Ubiquitin-like modifier-activating enzyme ATG7
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000407 [pre-autophagosomal structure]
GO:0004839 [ubiquitin activating enzyme activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005930 [axoneme]
GO:0006464 [cellular protein modification process]
GO:0006497 [protein lipidation]
GO:0006501 [C-terminal protein lipidation]
GO:0006914 [autophagy]
GO:0006995 [cellular response to nitrogen starvation]
GO:0008134 [transcription factor binding]
GO:0008641 [small protein activating enzyme activity]
GO:0009267 [cellular response to starvation]
GO:0010508 [positive regulation of autophagy]
GO:0015031 [protein transport]
GO:0016236 [macroautophagy]
GO:0016239 [positive regulation of macroautophagy]
GO:0016567 [protein ubiquitination]
GO:0019778 [Atg12 activating enzyme activity]
GO:0019779 [Atg8 activating enzyme activity]
GO:0031401 [positive regulation of protein modification process]
GO:0034727 [piecemeal microautophagy of nucleus]
GO:0039521 [suppression by virus of host autophagy]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0044805 [late nucleophagy]
GO:0045732 [positive regulation of protein catabolic process]
GO:0051607 [defense response to virus]
GO:0061025 [membrane fusion]
GO:0071455 [cellular response to hyperoxia]
GO:1903146 [regulation of mitophagy]
Show all
 676 aa
75 kDa 		No 0
ATG7-005
ENSP00000389996
ENST00000444619
C9JKA3 [Direct mapping]
Ubiquitin-like modifier-activating enzyme ATG7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 93 aa
10.1 kDa 		No 0
ATG7-006
ENSP00000408303
ENST00000419112
C9JNU2 [Direct mapping]
Ubiquitin-like modifier-activating enzyme ATG7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 89 aa
9.7 kDa 		No 0
ATG7-007
ENSP00000390547
ENST00000435760
C9JGL2 [Direct mapping]
Ubiquitin-like modifier-activating enzyme ATG7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 66 aa
7.3 kDa 		No 0
ATG7-008
ENSP00000416644
ENST00000423116
C9JE55 [Direct mapping]
Ubiquitin-like modifier-activating enzyme ATG7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 126 aa
13.8 kDa 		No 0
ATG7-009
ENSP00000415223
ENST00000451513
C9JFF4 [Direct mapping]
Ubiquitin-like modifier-activating enzyme ATG7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 176 aa
19.7 kDa 		No 0
ATG7-010
ENSP00000411880
ENST00000451830
C9J415 [Direct mapping]
Ubiquitin-like modifier-activating enzyme ATG7
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 152 aa
16.7 kDa 		No 0
ATG7-020
ENSP00000407340
ENST00000414717
H7C2R3 [Direct mapping]
Ubiquitin-like modifier-activating enzyme ATG7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0006914 [autophagy]
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 95 aa
10.6 kDa 		No 0
ATG7-021
ENSP00000388295
ENST00000427759
H7BZ92 [Direct mapping]
Ubiquitin-like modifier-activating enzyme ATG7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0006914 [autophagy]
Show all
 96 aa
10.5 kDa 		No 0
ATG7-022
ENSP00000406398
ENST00000446110
H7C2J8 [Direct mapping]
Ubiquitin-like modifier-activating enzyme ATG7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0006914 [autophagy]
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 139 aa
15.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.