Expression of PIGN in cancer - Summary - The Human Protein Atlas

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PIGN

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PIGN
Gene description	Phosphatidylinositol glycan anchor biosynthesis, class N
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression. Additional nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA039922 , HPA040374
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039922	HPA040374

GENE INFORMATION
Gene name	PIGN (HGNC Symbol)
Synonyms	MDC4, PIG-N
Description	Phosphatidylinositol glycan anchor biosynthesis, class N (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is expressed in the endoplasmic reticulum and transfers phosphoethanolamine (EtNP) to the first mannose of the GPI anchor. Two alternatively spliced variants, which encode an identical isoform, have been reported. [provided by RefSeq, Jul 2008]
Chromosome	18
Cytoband	q21.33
Chromosome location (bp)	62043567 - 62187118
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197563 (version 83.38)
Entrez gene	23556
UniProt	O95427 (UniProt - Evidence at protein level)
neXtProt	NX_O95427
Antibodypedia	PIGN antibodies

PROTEIN BROWSER

PIGN-001	PIGN-002	PIGN-003	PIGN-004	PIGN-005	PIGN-006	PIGN-007	PIGN-008	PIGN-009	PIGN-010	PIGN-012	PIGN-013	PIGN-014	PIGN-015	PIGN-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PIGN-001 ENSP00000350263 ENST00000357637	O95427 [Direct mapping] GPI ethanolamine phosphate transferase 1 A0A024R2C3 [Target identity:100%; Query identity:100%] Phosphatidylinositol glycan, class N, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0016740 [transferase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0051377 [mannose-ethanolamine phosphotransferase activity] Show all	931 aa 105.8 kDa	No	>9
PIGN-002 ENSP00000465897 ENST00000585344	K7EL34 [Direct mapping] GPI ethanolamine phosphate transferase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006506 [GPI anchor biosynthetic process] GO:0008152 [metabolic process] GO:0016740 [transferase activity] Show all	89 aa 10.1 kDa	No	0
PIGN-003 ENSP00000466035 ENST00000588571	K7ELE1 [Direct mapping] GPI ethanolamine phosphate transferase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006506 [GPI anchor biosynthetic process] GO:0008152 [metabolic process] GO:0016740 [transferase activity] Show all	116 aa 13 kDa	No	0
PIGN-004 ENSP00000383188 ENST00000400334	O95427 [Direct mapping] GPI ethanolamine phosphate transferase 1 A0A024R2C3 [Target identity:100%; Query identity:100%] Phosphatidylinositol glycan, class N, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0016740 [transferase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0051377 [mannose-ethanolamine phosphotransferase activity] Show all	931 aa 105.8 kDa	No	>9
PIGN-005 ENSP00000468721 ENST00000589720	K7ESH9 [Direct mapping] GPI ethanolamine phosphate transferase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006506 [GPI anchor biosynthetic process] GO:0008152 [metabolic process] GO:0016740 [transferase activity] Show all	189 aa 21.4 kDa	No	0
PIGN-006 ENSP00000468456 ENST00000585926	K7ERX5 [Direct mapping] GPI ethanolamine phosphate transferase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006506 [GPI anchor biosynthetic process] GO:0016740 [transferase activity] Show all	83 aa 9.5 kDa	No	0
PIGN-007 ENSP00000467812 ENST00000585923	K7EQG0 [Direct mapping] GPI ethanolamine phosphate transferase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006506 [GPI anchor biosynthetic process] GO:0008152 [metabolic process] GO:0016740 [transferase activity] Show all	192 aa 21.8 kDa	No	0
PIGN-008 ENSP00000465506 ENST00000589339	K7EK83 [Direct mapping] GPI ethanolamine phosphate transferase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006506 [GPI anchor biosynthetic process] GO:0008152 [metabolic process] GO:0016740 [transferase activity] Show all	93 aa 10.6 kDa	No	0
PIGN-009 ENSP00000464707 ENST00000590765	K7EID9 [Direct mapping] GPI ethanolamine phosphate transferase 1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006506 [GPI anchor biosynthetic process] GO:0008152 [metabolic process] GO:0016740 [transferase activity] Show all	140 aa 15.7 kDa	No	0
PIGN-010 ENSP00000466354 ENST00000587134	K7EM45 [Direct mapping] GPI ethanolamine phosphate transferase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		33 aa 3.8 kDa	No	0
PIGN-012 ENSP00000466883 ENST00000585458	K7ENC3 [Direct mapping] GPI ethanolamine phosphate transferase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006506 [GPI anchor biosynthetic process] GO:0016740 [transferase activity] Show all	84 aa 9.4 kDa	No	0
PIGN-013 ENSP00000466462 ENST00000591238	K7EMD7 [Direct mapping] GPI ethanolamine phosphate transferase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006506 [GPI anchor biosynthetic process] GO:0008152 [metabolic process] GO:0016740 [transferase activity] Show all	122 aa 13.9 kDa	No	0
PIGN-014 ENSP00000467458 ENST00000588748	K7EPN0 [Direct mapping] GPI ethanolamine phosphate transferase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006506 [GPI anchor biosynthetic process] GO:0008152 [metabolic process] GO:0016740 [transferase activity] Show all	183 aa 20.9 kDa	No	0
PIGN-015 ENSP00000467618 ENST00000589098	K7EQ07 [Direct mapping] GPI ethanolamine phosphate transferase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006506 [GPI anchor biosynthetic process] GO:0016740 [transferase activity] Show all	103 aa 11.7 kDa	No	0
PIGN-018 ENSP00000467410 ENST00000586566	K7EPJ2 [Direct mapping] GPI ethanolamine phosphate transferase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006506 [GPI anchor biosynthetic process] GO:0016021 [integral component of membrane] GO:0016740 [transferase activity] Show all	112 aa 12.8 kDa	No	2

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The Human Protein Atlas

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