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HOXA4

GENERAL INFORMATION

Gene name

 HOXA4

Gene description

 Homeobox A4

Protein class

 Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (AN3-CA, WM-115)
HPA (normal tissue):Tissue enhanced (fallopian tube, parathyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA060088
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA060088

GENE INFORMATION

Gene name

 HOXA4 (HGNC Symbol)

Synonyms

 HOX1, HOX1D

Description

 Homeobox A4 (HGNC Symbol)

Entrez gene summary

 In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 p15.2

Chromosome location (bp)

 27128507 - 27130799

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197576 (version 83.38)

Entrez gene

 3201

UniProt

 Q00056 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q00056

Antibodypedia

 HOXA4 antibodies

PROTEIN BROWSER
HOXA4-001
HOXA4-004
HOXA4-201
HOXA4-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HOXA4-001
ENSP00000353151
ENST00000360046
Q00056 [Direct mapping]
Homeobox protein Hox-A4
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Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
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GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0009653 [anatomical structure morphogenesis]
GO:0043565 [sequence-specific DNA binding]
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 320 aa
34.5 kDa 		No 0
HOXA4-004
ENSP00000448015
ENST00000511914
H0YHX3 [Direct mapping]
Homeobox protein Hox-A4
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Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0043565 [sequence-specific DNA binding]
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 140 aa
16 kDa 		No 0
HOXA4-201
ENSP00000408845
ENST00000428284
Q00056 [Direct mapping]
Homeobox protein Hox-A4
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0009653 [anatomical structure morphogenesis]
GO:0043565 [sequence-specific DNA binding]
Show all
 320 aa
34.5 kDa 		No 0
HOXA4-202
ENSP00000479166
ENST00000610970
Q00056 [Direct mapping]
Homeobox protein Hox-A4
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0009653 [anatomical structure morphogenesis]
GO:0043565 [sequence-specific DNA binding]
Show all
 320 aa
34.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.