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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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TOPORS
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

TOPORS

Gene description

Topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA065661
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable) and ovarian cancer (favourable).
Renal cancer p<0.001
Ovarian cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA065661

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues showed moderate to strong nuclear and perinuclear granular cytoplasmic staining.

GENE INFORMATION

Gene name

TOPORS (HGNC Symbol)

Synonyms

LUN, RP31, TP53BPL

Description

Topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010]

Chromosome

9

Cytoband

p21.1

Chromosome location (bp)

32540544 - 32552553

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197579 (version 83.38)

Entrez gene

10210

UniProt

Q9NS56 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NS56

Antibodypedia

TOPORS antibodies

PROTEIN BROWSER

TOPORS-001
TOPORS-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TOPORS-001
ENSP00000353735
ENST00000360538
Q9NS56 [Direct mapping]
E3 ubiquitin-protein ligase Topors
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000922 [spindle pole]
GO:0000930 [gamma-tubulin complex]
GO:0003677 [DNA binding]
GO:0003823 [antigen binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005814 [centriole]
GO:0005868 [cytoplasmic dynein complex]
GO:0006351 [transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006513 [protein monoubiquitination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008270 [zinc ion binding]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010842 [retina layer formation]
GO:0016605 [PML body]
GO:0016607 [nuclear speck]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0030496 [midbody]
GO:0032391 [photoreceptor connecting cilium]
GO:0034504 [protein localization to nucleus]
GO:0035845 [photoreceptor cell outer segment organization]
GO:0036064 [ciliary basal body]
GO:0042127 [regulation of cell proliferation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044547 [DNA topoisomerase binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046548 [retinal rod cell development]
GO:0046549 [retinal cone cell development]
GO:0046872 [metal ion binding]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0051457 [maintenance of protein location in nucleus]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
Show all
1045 aa
119.2 kDa
No 0
TOPORS-002
ENSP00000369187
ENST00000379858
Q9NS56 [Direct mapping]
E3 ubiquitin-protein ligase Topors
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000922 [spindle pole]
GO:0000930 [gamma-tubulin complex]
GO:0003677 [DNA binding]
GO:0003823 [antigen binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005814 [centriole]
GO:0005868 [cytoplasmic dynein complex]
GO:0006351 [transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006513 [protein monoubiquitination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008270 [zinc ion binding]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010842 [retina layer formation]
GO:0016605 [PML body]
GO:0016607 [nuclear speck]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0030496 [midbody]
GO:0032391 [photoreceptor connecting cilium]
GO:0034504 [protein localization to nucleus]
GO:0035845 [photoreceptor cell outer segment organization]
GO:0036064 [ciliary basal body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044547 [DNA topoisomerase binding]
GO:0046548 [retinal rod cell development]
GO:0046549 [retinal cone cell development]
GO:0046872 [metal ion binding]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0051457 [maintenance of protein location in nucleus]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
Show all
980 aa
112.3 kDa
No 0

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