Expression of KCNMB2 in cancer - Summary - The Human Protein Atlas

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KCNMB2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KCNMB2
Gene description	Potassium channel subfamily M regulatory beta subunit 2
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (BJ hTERT+, SCLC-21H)
HPA (normal tissue):	Tissue enhanced (epididymis, fallopian tube, ovary)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. CAB022649
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB022649

GENE INFORMATION
Gene name	KCNMB2
Synonyms
Description	Potassium channel subfamily M regulatory beta subunit 2 (HGNC Symbol)
Entrez gene summary	MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013]
Chromosome	3
Cytoband	q26.32
Chromosome location (bp)	178272932 - 178844429
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197584 (version 83.38)
Entrez gene	10242
UniProt	Q9Y691 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y691
Antibodypedia	KCNMB2 antibodies

PROTEIN BROWSER

KCNMB2-001	KCNMB2-002	KCNMB2-003	KCNMB2-004	KCNMB2-012	KCNMB2-201	KCNMB2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNMB2-001 ENSP00000397483 ENST00000452583	Q9Y691 [Direct mapping] Calcium-activated potassium channel subunit beta-2 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001508 [action potential] GO:0005513 [detection of calcium ion] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008076 [voltage-gated potassium channel complex] GO:0008200 [ion channel inhibitor activity] GO:0015269 [calcium-activated potassium channel activity] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0019228 [neuronal action potential] GO:0019229 [regulation of vasoconstriction] GO:0071805 [potassium ion transmembrane transport] Show all	235 aa 27.1 kDa	No	2
KCNMB2-002 ENSP00000395807 ENST00000437510	E7ETM2 [Direct mapping] Calcium-activated potassium channel subunit beta-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0071805 [potassium ion transmembrane transport] Show all	137 aa 15.8 kDa	No	1
KCNMB2-003 ENSP00000407592 ENST00000432997	Q9Y691 [Direct mapping] Calcium-activated potassium channel subunit beta-2 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001508 [action potential] GO:0005513 [detection of calcium ion] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008076 [voltage-gated potassium channel complex] GO:0008200 [ion channel inhibitor activity] GO:0015269 [calcium-activated potassium channel activity] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0019228 [neuronal action potential] GO:0019229 [regulation of vasoconstriction] GO:0071805 [potassium ion transmembrane transport] Show all	235 aa 27.1 kDa	No	2
KCNMB2-004 ENSP00000408252 ENST00000420517	Q9Y691 [Direct mapping] Calcium-activated potassium channel subunit beta-2 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0001508 [action potential] GO:0005513 [detection of calcium ion] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008076 [voltage-gated potassium channel complex] GO:0008200 [ion channel inhibitor activity] GO:0015269 [calcium-activated potassium channel activity] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0019228 [neuronal action potential] GO:0019229 [regulation of vasoconstriction] GO:0071805 [potassium ion transmembrane transport] Show all	235 aa 27.1 kDa	No	2
KCNMB2-012 ENSP00000399100 ENST00000455865	E7EM81 [Direct mapping] Calcium-activated potassium channel subunit beta-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0071805 [potassium ion transmembrane transport] Show all	100 aa 11.6 kDa	No	1
KCNMB2-201 ENSP00000351068 ENST00000358316	Q9Y691 [Direct mapping] Calcium-activated potassium channel subunit beta-2 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0001508 [action potential] GO:0005513 [detection of calcium ion] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008076 [voltage-gated potassium channel complex] GO:0008200 [ion channel inhibitor activity] GO:0015269 [calcium-activated potassium channel activity] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0019228 [neuronal action potential] GO:0019229 [regulation of vasoconstriction] GO:0071805 [potassium ion transmembrane transport] Show all	235 aa 27.1 kDa	No	2
KCNMB2-202 ENSP00000484788 ENST00000617329	B5BNW5 [Direct mapping] Calcium-activated potassium channel subunit beta-2; Large-conductance Ca2+-activated K+ channel beta2 subunit Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0071805 [potassium ion transmembrane transport] Show all	216 aa 25 kDa	No	2

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