Expression of DNAH10 in cancer - Summary - The Human Protein Atlas

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DNAH10

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DNAH10
Gene description	Dynein, axonemal, heavy chain 10
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (testis cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (fallopian tube, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 2 antibodies. HPA039065 , HPA039066
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039065	HPA039066

GENE INFORMATION
Gene name	DNAH10 (HGNC Symbol)
Synonyms	FLJ43808
Description	Dynein, axonemal, heavy chain 10 (HGNC Symbol)
Entrez gene summary	Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH10 is an inner arm dynein heavy chain (Maiti et al., 2000 [PubMed 11175280]).[supplied by OMIM, Mar 2008]
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	123762188 - 123936206
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197653 (version 83.38)
Entrez gene	196385
UniProt	Q8IVF4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IVF4
Antibodypedia	DNAH10 antibodies

PROTEIN BROWSER

DNAH10-001	DNAH10-007	DNAH10-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DNAH10-001 ENSP00000386770 ENST00000409039	Q8IVF4 [Direct mapping] Dynein heavy chain 10, axonemal Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003777 [microtubule motor activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0005929 [cilium] GO:0007018 [microtubule-based movement] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] GO:0030286 [dynein complex] Show all	4471 aa 514.8 kDa	No	0
DNAH10-007 ENSP00000445308 ENST00000540041	H0YGZ2 [Direct mapping] Dynein heavy chain 10, axonemal Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0003777 [microtubule motor activity] GO:0007018 [microtubule-based movement] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] Show all	319 aa 36.3 kDa	No	0
DNAH10-201 ENSP00000479072 ENST00000614082	A0A087WV07 [Direct mapping] Dynein heavy chain 10, axonemal Show all	Predicted intracellular proteins Show all	GO:0003777 [microtubule motor activity] GO:0007018 [microtubule-based movement] GO:0008152 [metabolic process] Show all	970 aa 113.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.