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Most cancer cells showed strong membranous staining with additional weaker cytoplasmic positivity. Carcinoids, gliomas and lymphomas were in general weakly stained or negative.
Cancer tissues generally showed weak cytoplasmic and/or membranous immunoreactivity or were negative. Pancreatic cancers as well as several cases of urothelial and renal cancers showed moderate staining.
GENE INFORMATION
Gene name
S100A10 (HGNC Symbol)
Synonyms
42C, ANX2LG, CAL1L, CLP11, P11
Description
S100 calcium binding protein A10 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided by RefSeq, Jul 2008]