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TAF13

GENERAL INFORMATION

Gene name

 TAF13

Gene description

 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nuclear expression in several different tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA044492
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and ovarian cancer (favourable).
Liver cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044492

GENE INFORMATION

Gene name

 TAF13 (HGNC Symbol)

Synonyms

 TAF2K, TAFII18

Description

 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa (HGNC Symbol)

Entrez gene summary

 Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p13.3

Chromosome location (bp)

 109062486 - 109076002

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197780 (version 83.38)

Entrez gene

 6884

UniProt

 Q15543 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15543

Antibodypedia

 TAF13 antibodies

PROTEIN BROWSER
TAF13-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TAF13-002
ENSP00000355051
ENST00000338366
Q15543 [Direct mapping]
Transcription initiation factor TFIID subunit 13
A0A024R089 [Target identity:100%; Query identity:100%]
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0046982 [protein heterodimerization activity]
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 124 aa
14.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.