Cell atlas - ATAD3A - The Human Protein Atlas

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ATAD3A

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	ATAD3A
Gene description	ATPase family, AAA domain containing 3A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA064867 , HPA065305
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA064867	CACO-2	Mitochondria
HPA064867	PC-3	Mitochondria
HPA064867	U-2 OS	Mitochondria
HPA065305	CACO-2	Mitochondria
HPA065305	PC-3	No staining
HPA065305	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	ATAD3A (HGNC Symbol)
Synonyms	FLJ10709
Description	ATPase family, AAA domain containing 3A (HGNC Symbol)
Entrez gene summary	ATAD3A and ATAD3B (MIM 612317) are mitochondrial membrane proteins that contribute to the stabilization of large mitochondrial DNA (mtDNA)-protein complexes called nucleoids (He et al., 2007 [PubMed 17210950]).[supplied by OMIM, Sep 2008]
Chromosome	1
Cytoband	p36.33
Chromosome location (bp)	1512151 - 1534687
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197785 (version 83.38)
Entrez gene	55210
UniProt	Q9NVI7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NVI7
Antibodypedia	ATAD3A antibodies

PROTEIN BROWSER

ATAD3A-001	ATAD3A-002	ATAD3A-003	ATAD3A-006	ATAD3A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATAD3A-001 ENSP00000368031 ENST00000378756	Q9NVI7 [Direct mapping] ATPase family AAA domain-containing protein 3A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0016021 [integral component of membrane] GO:0016049 [cell growth] GO:0042645 [mitochondrial nucleoid] GO:0043066 [negative regulation of apoptotic process] Show all	586 aa 66.2 kDa	No	0
ATAD3A-002 ENSP00000339421 ENST00000339113	H0Y2W2 [Direct mapping] ATPase family AAA domain-containing protein 3A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] Show all	572 aa 64.2 kDa	No	0
ATAD3A-003 ENSP00000368030 ENST00000378755	Q9NVI7 [Direct mapping] ATPase family AAA domain-containing protein 3A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0016021 [integral component of membrane] GO:0016049 [cell growth] GO:0042645 [mitochondrial nucleoid] GO:0043066 [negative regulation of apoptotic process] Show all	634 aa 71.4 kDa	No	0
ATAD3A-006 ENSP00000383631 ENST00000400830	Q5SV16 [Direct mapping] ATPase family AAA domain-containing protein 3A Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] Show all	201 aa 22.9 kDa	No	0
ATAD3A-201 ENSP00000439290 ENST00000536055	Q9NVI7 [Direct mapping] ATPase family AAA domain-containing protein 3A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0016021 [integral component of membrane] GO:0016049 [cell growth] GO:0042645 [mitochondrial nucleoid] GO:0043066 [negative regulation of apoptotic process] Show all	507 aa 57.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.