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SLC22A12

GENERAL INFORMATION

Gene name

 SLC22A12

Gene description

 Solute carrier family 22 (organic anion/urate transporter), member 12

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (liver cancer, renal cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (kidney)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct membranous expression in renal proximal tubules.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA024575
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (liver cancer, renal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY
HPA024575

GENE INFORMATION

Gene name

 SLC22A12 (HGNC Symbol)

Synonyms

 OAT4L, RST, URAT1

Description

 Solute carrier family 22 (organic anion/urate transporter), member 12 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 64590641 - 64602353

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197891 (version 83.38)

Entrez gene

 116085

UniProt

 Q96S37 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96S37

Antibodypedia

 SLC22A12 antibodies

PROTEIN BROWSER
SLC22A12-001
SLC22A12-002
SLC22A12-004
SLC22A12-005
SLC22A12-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC22A12-001
ENSP00000366797
ENST00000377574
Q96S37 [Direct mapping]
Solute carrier family 22 member 12
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0015143 [urate transmembrane transporter activity]
GO:0015347 [sodium-independent organic anion transmembrane transporter activity]
GO:0015747 [urate transport]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0019725 [cellular homeostasis]
GO:0030165 [PDZ domain binding]
GO:0031526 [brush border membrane]
GO:0042493 [response to drug]
GO:0043252 [sodium-independent organic anion transport]
GO:0046415 [urate metabolic process]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0098656 [anion transmembrane transport]
GO:1903825 [organic acid transmembrane transport]
Show all
 553 aa
59.6 kDa 		No >9
SLC22A12-002
ENSP00000366790
ENST00000377567
Q96S37 [Direct mapping]
Solute carrier family 22 member 12
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0015143 [urate transmembrane transporter activity]
GO:0015347 [sodium-independent organic anion transmembrane transporter activity]
GO:0015747 [urate transport]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0019725 [cellular homeostasis]
GO:0022857 [transmembrane transporter activity]
GO:0030165 [PDZ domain binding]
GO:0031526 [brush border membrane]
GO:0042493 [response to drug]
GO:0043252 [sodium-independent organic anion transport]
GO:0046415 [urate metabolic process]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0098656 [anion transmembrane transport]
GO:1903825 [organic acid transmembrane transport]
Show all
 445 aa
47.6 kDa 		No 8
SLC22A12-004
ENSP00000438437
ENST00000473690
Q96S37 [Direct mapping]
Solute carrier family 22 member 12
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0015143 [urate transmembrane transporter activity]
GO:0015347 [sodium-independent organic anion transmembrane transporter activity]
GO:0015747 [urate transport]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0019725 [cellular homeostasis]
GO:0022857 [transmembrane transporter activity]
GO:0030165 [PDZ domain binding]
GO:0031526 [brush border membrane]
GO:0042493 [response to drug]
GO:0043252 [sodium-independent organic anion transport]
GO:0046415 [urate metabolic process]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0098656 [anion transmembrane transport]
GO:1903825 [organic acid transmembrane transport]
Show all
 332 aa
35.6 kDa 		No 8
SLC22A12-005
ENSP00000336836
ENST00000336464
Q96S37 [Direct mapping]
Solute carrier family 22 member 12
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0015143 [urate transmembrane transporter activity]
GO:0015347 [sodium-independent organic anion transmembrane transporter activity]
GO:0015747 [urate transport]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0019725 [cellular homeostasis]
GO:0022857 [transmembrane transporter activity]
GO:0030165 [PDZ domain binding]
GO:0031526 [brush border membrane]
GO:0042493 [response to drug]
GO:0043252 [sodium-independent organic anion transport]
GO:0046415 [urate metabolic process]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0098656 [anion transmembrane transport]
GO:1903825 [organic acid transmembrane transport]
Show all
 519 aa
56.1 kDa 		No >9
SLC22A12-201
ENSP00000366795
ENST00000377572
Q96S37 [Direct mapping]
Solute carrier family 22 member 12
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0015143 [urate transmembrane transporter activity]
GO:0015347 [sodium-independent organic anion transmembrane transporter activity]
GO:0015747 [urate transport]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0019725 [cellular homeostasis]
GO:0022857 [transmembrane transporter activity]
GO:0030165 [PDZ domain binding]
GO:0031526 [brush border membrane]
GO:0042493 [response to drug]
GO:0043252 [sodium-independent organic anion transport]
GO:0046415 [urate metabolic process]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0098656 [anion transmembrane transport]
GO:1903825 [organic acid transmembrane transport]
Show all
 445 aa
47.6 kDa 		No 8

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.