Fields »
ABOUT
HELP
BLOG
NRAP

GENERAL INFORMATION

Gene name

 NRAP

Gene description

 Nebulin-related anchoring protein

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (head and neck cancer, prostate cancer)
HPA (cell line):Not detected
HPA (normal tissue):Group enriched (heart muscle, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in a subset of tissues most abundant in myocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA037953 , HPA037954
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (head and neck cancer, prostate cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037953
HPA037954

GENE INFORMATION

Gene name

 NRAP

Synonyms

Description

 Nebulin-related anchoring protein (HGNC Symbol)

Entrez gene summary

Chromosome

 10

Cytoband

 q25.3

Chromosome location (bp)

 113588716 - 113664127

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197893 (version 83.38)

Entrez gene

 4892

UniProt

 Q86VF7 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q86VF7

Antibodypedia

 NRAP antibodies

PROTEIN BROWSER
NRAP-001
NRAP-003
NRAP-201
NRAP-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NRAP-001
ENSP00000353078
ENST00000359988
Q86VF7 [Direct mapping]
Nebulin-related-anchoring protein
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005916 [fascia adherens]
GO:0005927 [muscle tendon junction]
GO:0008150 [biological_process]
GO:0008270 [zinc ion binding]
GO:0051371 [muscle alpha-actinin binding]
Show all
 1730 aa
197.1 kDa 		No 0
NRAP-003
ENSP00000358367
ENST00000369360
Q86VF7 [Direct mapping]
Nebulin-related-anchoring protein
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005916 [fascia adherens]
GO:0005927 [muscle tendon junction]
GO:0008150 [biological_process]
GO:0008270 [zinc ion binding]
GO:0051371 [muscle alpha-actinin binding]
Show all
 1703 aa
193.9 kDa 		No 0
NRAP-201
ENSP00000353666
ENST00000360478
Q86VF7 [Direct mapping]
Nebulin-related-anchoring protein
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005916 [fascia adherens]
GO:0005927 [muscle tendon junction]
GO:0008150 [biological_process]
GO:0008270 [zinc ion binding]
GO:0051371 [muscle alpha-actinin binding]
Show all
 1695 aa
193 kDa 		No 0
NRAP-202
ENSP00000358365
ENST00000369358
A0A0A0MRM2 [Direct mapping]
Nebulin-related-anchoring protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005916 [fascia adherens]
GO:0005927 [muscle tendon junction]
GO:0008270 [zinc ion binding]
GO:0017166 [vinculin binding]
GO:0030016 [myofibril]
GO:0051371 [muscle alpha-actinin binding]
Show all
 1731 aa
197.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.