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SLC22A6

GENERAL INFORMATION

Gene name

 SLC22A6

Gene description

 Solute carrier family 22 (organic anion transporter), member 6

Protein class

 FDA approved drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (renal cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (kidney)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (renal cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 SLC22A6 (HGNC Symbol)

Synonyms

 OAT1, PAHT, ROAT1

Description

 Solute carrier family 22 (organic anion transporter), member 6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q12.3

Chromosome location (bp)

 62936385 - 62984983

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197901 (version 83.38)

Entrez gene

 9356

UniProt

 Q4U2R8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q4U2R8

Antibodypedia

 SLC22A6 antibodies

PROTEIN BROWSER
SLC22A6-001
SLC22A6-002
SLC22A6-003
SLC22A6-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC22A6-001
ENSP00000353597
ENST00000360421
Q4U2R8 [Direct mapping]
Solute carrier family 22 member 6
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005452 [inorganic anion exchanger activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015075 [ion transmembrane transporter activity]
GO:0015347 [sodium-independent organic anion transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0015742 [alpha-ketoglutarate transport]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0022857 [transmembrane transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0043252 [sodium-independent organic anion transport]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0097254 [renal tubular secretion]
GO:0098656 [anion transmembrane transport]
Show all
 550 aa
60.3 kDa 		No >9
SLC22A6-002
ENSP00000367102
ENST00000377871
Q4U2R8 [Direct mapping]
Solute carrier family 22 member 6
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005452 [inorganic anion exchanger activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005901 [caveola]
GO:0006820 [anion transport]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015075 [ion transmembrane transporter activity]
GO:0015301 [anion:anion antiporter activity]
GO:0015347 [sodium-independent organic anion transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0015742 [alpha-ketoglutarate transport]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0022857 [transmembrane transporter activity]
GO:0031404 [chloride ion binding]
GO:0031427 [response to methotrexate]
GO:0034220 [ion transmembrane transport]
GO:0042803 [protein homodimerization activity]
GO:0043234 [protein complex]
GO:0043252 [sodium-independent organic anion transport]
GO:0051260 [protein homooligomerization]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0097254 [renal tubular secretion]
GO:0098656 [anion transmembrane transport]
Show all
 563 aa
61.8 kDa 		No >9
SLC22A6-003
ENSP00000396401
ENST00000458333
Q4U2R8 [Direct mapping]
Solute carrier family 22 member 6
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005452 [inorganic anion exchanger activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015075 [ion transmembrane transporter activity]
GO:0015347 [sodium-independent organic anion transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0015742 [alpha-ketoglutarate transport]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0022857 [transmembrane transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0043252 [sodium-independent organic anion transport]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0097254 [renal tubular secretion]
GO:0098656 [anion transmembrane transport]
Show all
 506 aa
55.9 kDa 		No >9
SLC22A6-004
ENSP00000404441
ENST00000421062
Q4U2R8 [Direct mapping]
Solute carrier family 22 member 6
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005452 [inorganic anion exchanger activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015075 [ion transmembrane transporter activity]
GO:0015347 [sodium-independent organic anion transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0015742 [alpha-ketoglutarate transport]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0022857 [transmembrane transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0043252 [sodium-independent organic anion transport]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0097254 [renal tubular secretion]
GO:0098656 [anion transmembrane transport]
Show all
 519 aa
57.4 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.