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S100A6

GENERAL INFORMATION

Gene name

 S100A6

Gene description

 S100 calcium binding protein A6

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (RPTEC TERT1)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA007575 , CAB002601 , CAB040549
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA007575
CAB002601
CAB040549

GENE INFORMATION

Gene name

 S100A6 (HGNC Symbol)

Synonyms

 2A9, CABP, CACY, PRA

Description

 S100 calcium binding protein A6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 153534599 - 153536244

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197956 (version 83.38)

Entrez gene

 6277

UniProt

 P06703 (UniProt - Evidence at protein level)

neXtProt

 NX_P06703

Antibodypedia

 S100A6 antibodies

PROTEIN BROWSER
S100A6-006
S100A6-008
S100A6-009
S100A6-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
S100A6-006
ENSP00000473589
ENST00000496817
P06703 [Direct mapping]
Protein S100-A6
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005523 [tropomyosin binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007409 [axonogenesis]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042803 [protein homodimerization activity]
GO:0044548 [S100 protein binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
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 90 aa
10.2 kDa 		No 0
S100A6-008
ENSP00000357709
ENST00000368720
P06703 [Direct mapping]
Protein S100-A6
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005523 [tropomyosin binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007409 [axonogenesis]
GO:0008270 [zinc ion binding]
GO:0015075 [ion transmembrane transporter activity]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0034220 [ion transmembrane transport]
GO:0042803 [protein homodimerization activity]
GO:0044548 [S100 protein binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
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 90 aa
10.2 kDa 		No 0
S100A6-009
ENSP00000357708
ENST00000368719
P06703 [Direct mapping]
Protein S100-A6
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005523 [tropomyosin binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007409 [axonogenesis]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042803 [protein homodimerization activity]
GO:0044548 [S100 protein binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
Show all
 90 aa
10.2 kDa 		No 0
S100A6-010
ENSP00000473547
ENST00000462776
R4GN98 [Direct mapping]
Protein S100
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005737 [cytoplasm]
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 85 aa
9.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.