Expression of MPZL1 in cancer - Summary - The Human Protein Atlas

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MPZL1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MPZL1
Gene description	Myelin protein zero-like 1
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression with a granular pattern in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA026966
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), lung cancer (unfavourable) and thyroid cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Lung cancer p<0.001 Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA026966

GENE INFORMATION
Gene name	MPZL1 (HGNC Symbol)
Synonyms	FLJ21047, PZR
Description	Myelin protein zero-like 1 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q24.2
Chromosome location (bp)	167721192 - 167791919
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197965 (version 83.38)
Entrez gene	9019
UniProt	O95297 (UniProt - Evidence at protein level)
neXtProt	NX_O95297
Antibodypedia	MPZL1 antibodies

PROTEIN BROWSER

MPZL1-001	MPZL1-003	MPZL1-006	MPZL1-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MPZL1-001 ENSP00000352513 ENST00000359523	O95297 [Direct mapping] Myelin protein zero-like protein 1 A8K5D4 [Target identity:100%; Query identity:100%] Myelin protein zero-like 1, isoform CRA_b; cDNA FLJ78597, highly similar to Homo sapiens myelin protein zero-like 1 (MPZL1), transcript variant 1, mRNA; cDNA, FLJ96614, Homo sapiens myelin protein zero-like 1 (MPZL1), mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007267 [cell-cell signaling] GO:0009986 [cell surface] Show all	269 aa 29.1 kDa	Yes	1
MPZL1-003 ENSP00000356827 ENST00000367853	Q9UEL6 [Direct mapping] Myelin protein zero-like protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] Show all	183 aa 20.2 kDa	No	1
MPZL1-006 ENSP00000375968 ENST00000392121	O95297 [Direct mapping] Myelin protein zero-like protein 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007267 [cell-cell signaling] GO:0009986 [cell surface] Show all	119 aa 12.4 kDa	Yes	0
MPZL1-011 ENSP00000420455 ENST00000474859	O95297 [Direct mapping] Myelin protein zero-like protein 1 A0A024R8Y3 [Target identity:100%; Query identity:100%] Myelin protein zero-like 1, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007267 [cell-cell signaling] GO:0009986 [cell surface] Show all	209 aa 22.8 kDa	Yes	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.