Tissue expression of KEL - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	KEL
Gene description	Kell blood group, metallo-endopeptidase
Protein class	Blood group antigen proteins Cancer-related genes CD markers Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (bone marrow, testis)
GTEx:	Tissue enriched (testis)
FANTOM5:	Group enriched (testis, tonsil)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (bone marrow, testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (testis, tonsil)

GENE INFORMATION
Gene name	KEL (HGNC Symbol)
Synonyms	CD238, ECE3
Description	Kell blood group, metallo-endopeptidase (HGNC Symbol)
Entrez gene summary	This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q34
Chromosome location (bp)	142941114 - 142962681
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197993 (version 83.38)
Entrez gene	3792
UniProt	P23276 (UniProt - Evidence at protein level)
neXtProt	NX_P23276
Antibodypedia	KEL antibodies

PROTEIN BROWSER

KEL-001	KEL-003	KEL-004	KEL-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KEL-001 ENSP00000347409 ENST00000355265	P23276 [Direct mapping] Kell blood group glycoprotein A0A077QP03 [Target identity:100%; Query identity:100%] Kell blood group, metallo-endopeptidase Show all	Enzymes Peptidases Metallopeptidases CD markers Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0006874 [cellular calcium ion homeostasis] GO:0008237 [metallopeptidase activity] GO:0008361 [regulation of cell size] GO:0010961 [cellular magnesium ion homeostasis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031133 [regulation of axon diameter] GO:0042310 [vasoconstriction] GO:0042552 [myelination] GO:0046872 [metal ion binding] GO:0048741 [skeletal muscle fiber development] GO:1901380 [negative regulation of potassium ion transmembrane transport] Show all	732 aa 82.8 kDa	No	1
KEL-003 ENSP00000420011 ENST00000467543	E7ETW3 [Direct mapping] Kell blood group glycoprotein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	204 aa 23 kDa	No	1
KEL-004 ENSP00000418886 ENST00000460479	H0Y8A1 [Direct mapping] Kell blood group glycoprotein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	186 aa 20.6 kDa	No	1
KEL-005 ENSP00000419889 ENST00000476829	E9PHG0 [Direct mapping] Kell blood group glycoprotein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	184 aa 20.7 kDa	No	1