Expression of DLGAP2 in cancer - Summary - The Human Protein Atlas

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DLGAP2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DLGAP2
Gene description	Discs, large (Drosophila) homolog-associated protein 2
Protein class	Nuclear receptors Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (cerebral cortex, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results.
Reliability score	Uncertain based on 1 antibody. HPA030320
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030320

GENE INFORMATION
Gene name	DLGAP2 (HGNC Symbol)
Synonyms	DAP-2
Description	Discs, large (Drosophila) homolog-associated protein 2 (HGNC Symbol)
Entrez gene summary	The product of this gene is a membrane-associated protein that may play a role in synapse organization and signalling in neuronal cells. This gene is biallelically expressed in the brain, however, only the paternal allele is expressed in the testis (PMID:18055845). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2014]
Chromosome	8
Cytoband	p23.3
Chromosome location (bp)	1501366 - 1708476
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198010 (version 83.38)
Entrez gene	9228
UniProt	Q9P1A6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P1A6
Antibodypedia	DLGAP2 antibodies

PROTEIN BROWSER

DLGAP2-001	DLGAP2-003	DLGAP2-004	DLGAP2-005	DLGAP2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DLGAP2-001 ENSP00000400258 ENST00000421627	Q9P1A6 [Direct mapping] Disks large-associated protein 2 Show all	Nuclear receptors Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005883 [neurofilament] GO:0007270 [neuron-neuron synaptic transmission] GO:0014069 [postsynaptic density] GO:0023052 [signaling] GO:0030054 [cell junction] GO:0045211 [postsynaptic membrane] Show all	975 aa 108.9 kDa	No	0
DLGAP2-003 ENSP00000430563 ENST00000520901	H0YBY6 [Direct mapping] Disks large-associated protein 2 Show all	Predicted intracellular proteins Show all	GO:0007270 [neuron-neuron synaptic transmission] GO:0023052 [signaling] Show all	961 aa 107.2 kDa	No	0
DLGAP2-004 ENSP00000488445 ENST00000518530		Predicted intracellular proteins Show all	GO:0023052 [signaling] Show all	158 aa 18.1 kDa	No	0
DLGAP2-005 ENSP00000488645 ENST00000522499		Predicted intracellular proteins Show all	GO:0023052 [signaling] Show all	176 aa 19.8 kDa	No	0
DLGAP2-201 ENSP00000484215 ENST00000612087	A0A087X1H7 [Direct mapping] Disks large-associated protein 2 Show all	Predicted intracellular proteins Show all	GO:0023052 [signaling] Show all	961 aa 107.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.