Expression of FCGR1B in cancer - Summary - The Human Protein Atlas

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FCGR1B

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	FCGR1B
Gene description	Fc fragment of IgG, high affinity Ib, receptor (CD64)
Protein class	FDA approved drug targets Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma)
HPA (cell line):	Cell line enhanced (NB-4, THP-1)
HPA (normal tissue):	Tissue enhanced (appendix, epididymis)

Protein evidence

Evidence at transcript level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	FCGR1B (HGNC Symbol)
Synonyms	CD64b
Description	Fc fragment of IgG, high affinity Ib, receptor (CD64) (HGNC Symbol)
Entrez gene summary	Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene encodes the low affinity FcgammaRIB receptor that may play an important role in humoral immune response. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Chromosome	1
Cytoband	p11.2
Chromosome location (bp)	121087345 - 121096310
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000198019 (version 83.38)
Entrez gene	2210
UniProt	Q92637 (UniProt - Evidence at transcript level)
neXtProt	NX_Q92637
Antibodypedia	FCGR1B antibodies

PROTEIN BROWSER

FCGR1B-001	FCGR1B-002	FCGR1B-005	FCGR1B-009	FCGR1B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FCGR1B-001 ENSP00000358391 ENST00000369384	A0A0A0MRM3 [Direct mapping] High affinity immunoglobulin gamma Fc receptor IB Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	280 aa 32.2 kDa	Yes	1
FCGR1B-002 ENSP00000358390 ENST00000369383	Q92637 [Direct mapping] High affinity immunoglobulin gamma Fc receptor IB Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Biotech drugs Show all	GO:0002250 [adaptive immune response] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0019763 [immunoglobulin receptor activity] GO:0019864 [IgG binding] GO:0030669 [clathrin-coated endocytic vesicle membrane] GO:0031901 [early endosome membrane] GO:0038093 [Fc receptor signaling pathway] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0060333 [interferon-gamma-mediated signaling pathway] Show all	188 aa 22.1 kDa	Yes	1
FCGR1B-005 ENSP00000481411 ENST00000369178	A0A087WXZ6 [Direct mapping] High affinity immunoglobulin gamma Fc receptor IB Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	250 aa 29 kDa	No	1
FCGR1B-009 ENSP00000478655 ENST00000616817	A0A087WUG7 [Direct mapping] High affinity immunoglobulin gamma Fc receptor IB Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	225 aa 25.3 kDa	Yes	0
FCGR1B-201 ENSP00000485498 ENST00000623603	A0A087WVS4 [Direct mapping] High affinity immunoglobulin gamma Fc receptor IB Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	224 aa 25.2 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.