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TUBA3C

GENERAL INFORMATION

Gene name

 TUBA3C

Gene description

 Tubulin, alpha 3c

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (HDLM-2, U-2 OS, U-266/70, U-266/84)
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Uncertain based on 3 antibodies.
HPA039247 , HPA043684 , HPA063394
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA039247
HPA043684
HPA063394

GENE INFORMATION

Gene name

 TUBA3C (HGNC Symbol)

Synonyms

 bA408E5.3, TUBA2

Description

 Tubulin, alpha 3c (HGNC Symbol)

Entrez gene summary

 Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene is an alpha tubulin gene that encodes a protein 99% identical to the mouse testis-specific Tuba3 and Tuba7 gene products. This gene is located in the 13q11 region, which is associated with the genetic diseases Clouston hidrotic ectodermal dysplasia and Kabuki syndrome. [provided by RefSeq, Jul 2008]

Chromosome

 13

Cytoband

 q12.11

Chromosome location (bp)

 19173770 - 19181852

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198033 (version 83.38)

Entrez gene

 7278

UniProt

 Q13748 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13748

Antibodypedia

 TUBA3C antibodies

PROTEIN BROWSER
TUBA3C-002
TUBA3C-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TUBA3C-002
ENSP00000382982
ENST00000400113
Q13748 [Direct mapping]
Tubulin alpha-3C/D chain
Q1ZYQ1 [Target identity:100%; Query identity:100%]
Tubulin, alpha 2; Tubulin, alpha 2, isoform CRA_b; cDNA FLJ77591, highly similar to Homo sapiens tubulin, alpha 2 (TUBA2), transcript variant 1, mRNA
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
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GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0007017 [microtubule-based process]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051258 [protein polymerization]
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 450 aa
50 kDa 		No 0
TUBA3C-201
ENSP00000482878
ENST00000618094
Q13748 [Direct mapping]
Tubulin alpha-3C/D chain
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
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GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0007017 [microtubule-based process]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051258 [protein polymerization]
Show all
 418 aa
46.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.