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AVPR1B

GENERAL INFORMATION

Gene name

 AVPR1B

Gene description

 Arginine vasopressin receptor 1B

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (renal cancer)
HPA (cell line):Not detected
HPA (normal tissue):Not detected

Protein evidence

 Evidence at transcript level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 AVPR1B (HGNC Symbol)

Synonyms

 AVPR3

Description

 Arginine vasopressin receptor 1B (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 206109692 - 206117699

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000198049 (version 83.38)

Entrez gene

 553

UniProt

 P47901 (UniProt - Evidence at transcript level)

neXtProt

 NX_P47901

Antibodypedia

 AVPR1B antibodies

PROTEIN BROWSER
AVPR1B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AVPR1B-001
ENSP00000356094
ENST00000367126
P47901 [Direct mapping]
Vasopressin V1b receptor
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Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
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GO:0001992 [regulation of systemic arterial blood pressure by vasopressin]
GO:0004930 [G-protein coupled receptor activity]
GO:0005000 [vasopressin receptor activity]
GO:0005080 [protein kinase C binding]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0016021 [integral component of membrane]
GO:0032870 [cellular response to hormone stimulus]
GO:0042277 [peptide binding]
GO:0045907 [positive regulation of vasoconstriction]
GO:1901652 [response to peptide]
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 424 aa
47 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.