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PRIM1

GENERAL INFORMATION

Gene name

 PRIM1

Gene description

 Primase, DNA, polypeptide 1 (49kDa)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA040010
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY
HPA040010

GENE INFORMATION

Gene name

 PRIM1

Synonyms

Description

 Primase, DNA, polypeptide 1 (49kDa) (HGNC Symbol)

Entrez gene summary

 The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the small, 49 kDa primase subunit. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.3

Chromosome location (bp)

 56731596 - 56752373

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198056 (version 83.38)

Entrez gene

 5557

UniProt

 P49642 (UniProt - Evidence at protein level)

neXtProt

 NX_P49642

Antibodypedia

 PRIM1 antibodies

PROTEIN BROWSER
PRIM1-002
PRIM1-007
PRIM1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRIM1-002
ENSP00000350491
ENST00000338193
P49642 [Direct mapping]
DNA primase small subunit
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0003896 [DNA primase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006269 [DNA replication, synthesis of RNA primer]
GO:0006270 [DNA replication initiation]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0016020 [membrane]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0046872 [metal ion binding]
GO:1990077 [primosome complex]
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 420 aa
49.9 kDa 		No 0
PRIM1-007
ENSP00000450185
ENST00000550770
F8VNY2 [Direct mapping]
DNA primase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003896 [DNA primase activity]
GO:0006269 [DNA replication, synthesis of RNA primer]
GO:1990077 [primosome complex]
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 328 aa
39 kDa 		No 0
PRIM1-008
ENSP00000449806
ENST00000549549
H0YIP2 [Direct mapping]
DNA primase small subunit
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003896 [DNA primase activity]
GO:0006269 [DNA replication, synthesis of RNA primer]
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 152 aa
18 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.