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AKR1B10

GENERAL INFORMATION

Gene name

 AKR1B10

Gene description

 Aldo-keto reductase family 1, member B10 (aldose reductase)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (duodenum, gallbladder, small intestine, stomach)
GTEx:Tissue enhanced (esophagus, stomach)
FANTOM5:Tissue enhanced (esophagus, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in gastrointestinal tract and gall bladder.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 2 antibodies.
HPA020280 , CAB070163
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (duodenum, gallbladder, small intestine, stomach)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, stomach)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, small intestine)

GENE INFORMATION

Gene name

 AKR1B10 (HGNC Symbol)

Synonyms

 AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI

Description

 Aldo-keto reductase family 1, member B10 (aldose reductase) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q33

Chromosome location (bp)

 134527592 - 134541408

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198074 (version 83.38)

Entrez gene

 57016

UniProt

 O60218 (UniProt - Evidence at protein level)

neXtProt

 NX_O60218

Antibodypedia

 AKR1B10 antibodies

PROTEIN BROWSER
AKR1B10-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKR1B10-001
ENSP00000352584
ENST00000359579
O60218 [Direct mapping]
Aldo-keto reductase family 1 member B10
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001523 [retinoid metabolic process]
GO:0001758 [retinal dehydrogenase activity]
GO:0004033 [aldo-keto reductase (NADP) activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0006081 [cellular aldehyde metabolic process]
GO:0007586 [digestion]
GO:0007603 [phototransduction, visible light]
GO:0008202 [steroid metabolic process]
GO:0016488 [farnesol catabolic process]
GO:0016491 [oxidoreductase activity]
GO:0044597 [daunorubicin metabolic process]
GO:0044598 [doxorubicin metabolic process]
GO:0045550 [geranylgeranyl reductase activity]
GO:0047718 [indanol dehydrogenase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 316 aa
36 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.