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Several melanomas and hepatocellular carcinomas showed moderate to strong cytoplasmic positivity. A single case of adenocarcinoma of lung exhibited moderate nuclear immunoreactivity. Remaining cancer tissues were negative.
A majority of colorectal cancers along with several breast, ovarian, urothelial, stomach and pancreatic cancers displayed moderate cytoplasmic positivity with additional membranous staining in several cases. Several hepatocellular carcinomas were strongly stained. Remaining cancer cells were negative.
Strong cytoplasmic positivity was seen in a few cases of hepatocellular carcinomas. Remaining malignant cells were negative.
GENE INFORMATION
Gene name
CYP2A7 (HGNC Symbol)
Synonyms
CYP2A
Description
Cytochrome P450, family 2, subfamily A, polypeptide 7 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
GO:0005506 [iron ion binding] GO:0005737 [cytoplasm] GO:0006805 [xenobiotic metabolic process] GO:0008392 [arachidonic acid epoxygenase activity] GO:0008395 [steroid hydroxylase activity] GO:0009804 [coumarin metabolic process] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen] GO:0019373 [epoxygenase P450 pathway] GO:0020037 [heme binding] GO:0042738 [exogenous drug catabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process]