Tissue expression of LPAR1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	LPAR1
Gene description	Lysophosphatidic acid receptor 1
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	LPAR1 (HGNC Symbol)
Synonyms	edg-2, EDG2, Gpcr26, GPR26, LPA1, Mrec1.3, rec.1.3, vzg-1
Description	Lysophosphatidic acid receptor 1 (HGNC Symbol)
Entrez gene summary	The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q31.3
Chromosome location (bp)	110873263 - 111038458
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198121 (version 83.38)
Entrez gene	1902
UniProt	Q92633 (UniProt - Evidence at protein level)
neXtProt	NX_Q92633
Antibodypedia	LPAR1 antibodies

PROTEIN BROWSER

LPAR1-001	LPAR1-002	LPAR1-003	LPAR1-004	LPAR1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LPAR1-001 ENSP00000363553 ENST00000374431	Q92633 [Direct mapping] Lysophosphatidic acid receptor 1 Q5VZX0 [Target identity:100%; Query identity:100%] Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2, isoform CRA_a; cDNA FLJ12746 fis, clone NT2RP2000842, highly similar to Lysophosphatidic acid receptor Edg-2; cDNA FLJ78319, highly similar to Homo sapiens endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 (EDG2), transcript variant 2, mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Lysolipids receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0001965 [G-protein alpha-subunit binding] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007420 [brain development] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0010942 [positive regulation of cell death] GO:0010977 [negative regulation of neuron projection development] GO:0014003 [oligodendrocyte development] GO:0016021 [integral component of membrane] GO:0021549 [cerebellum development] GO:0021554 [optic nerve development] GO:0022008 [neurogenesis] GO:0022038 [corpus callosum development] GO:0030139 [endocytic vesicle] GO:0030165 [PDZ domain binding] GO:0030818 [negative regulation of cAMP biosynthetic process] GO:0032060 [bleb assembly] GO:0035025 [positive regulation of Rho protein signal transduction] GO:0035727 [lysophosphatidic acid binding] GO:0042552 [myelination] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0043065 [positive regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043197 [dendritic spine] GO:0043198 [dendritic shaft] GO:0043410 [positive regulation of MAPK cascade] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0051496 [positive regulation of stress fiber assembly] GO:0060326 [cell chemotaxis] GO:0060999 [positive regulation of dendritic spine development] GO:0070915 [lysophosphatidic acid receptor activity] GO:0071453 [cellular response to oxygen levels] GO:0071673 [positive regulation of smooth muscle cell chemotaxis] GO:1904566 [cellular response to 1-oleoyl-sn-glycerol 3-phosphate] Show all	364 aa 41.1 kDa	No	7
LPAR1-002 ENSP00000363552 ENST00000374430	Q92633 [Direct mapping] Lysophosphatidic acid receptor 1 Q5VZX0 [Target identity:100%; Query identity:100%] Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2, isoform CRA_a; cDNA FLJ12746 fis, clone NT2RP2000842, highly similar to Lysophosphatidic acid receptor Edg-2; cDNA FLJ78319, highly similar to Homo sapiens endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 (EDG2), transcript variant 2, mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Lysolipids receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005768 [endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0010977 [negative regulation of neuron projection development] GO:0016021 [integral component of membrane] GO:0030139 [endocytic vesicle] GO:0035025 [positive regulation of Rho protein signal transduction] GO:0035727 [lysophosphatidic acid binding] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043410 [positive regulation of MAPK cascade] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0051496 [positive regulation of stress fiber assembly] GO:0060326 [cell chemotaxis] GO:0070915 [lysophosphatidic acid receptor activity] Show all	364 aa 41.1 kDa	No	7
LPAR1-003 ENSP00000351755 ENST00000358883	Q92633 [Direct mapping] Lysophosphatidic acid receptor 1 Q5VZX0 [Target identity:100%; Query identity:100%] Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2, isoform CRA_a; cDNA FLJ12746 fis, clone NT2RP2000842, highly similar to Lysophosphatidic acid receptor Edg-2; cDNA FLJ78319, highly similar to Homo sapiens endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 (EDG2), transcript variant 2, mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Lysolipids receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005768 [endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0010977 [negative regulation of neuron projection development] GO:0016021 [integral component of membrane] GO:0030139 [endocytic vesicle] GO:0035025 [positive regulation of Rho protein signal transduction] GO:0035727 [lysophosphatidic acid binding] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043410 [positive regulation of MAPK cascade] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0051496 [positive regulation of stress fiber assembly] GO:0060326 [cell chemotaxis] GO:0070915 [lysophosphatidic acid receptor activity] Show all	364 aa 41.1 kDa	No	7
LPAR1-004 ENSP00000401810 ENST00000441240	B1AP63 [Direct mapping] Lysophosphatidic acid receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0070915 [lysophosphatidic acid receptor activity] Show all	182 aa 20.6 kDa	No	4
LPAR1-201 ENSP00000445697 ENST00000541779	Q6GPG7 [Direct mapping] LPAR1 protein; Lysophosphatidic acid receptor 1; cDNA FLJ51746, highly similar to Lysophosphatidic acid receptor Edg-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0070915 [lysophosphatidic acid receptor activity] Show all	346 aa 39.3 kDa	No	7