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RNA tissue category: Group enriched (cervix, uterine, lung)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (lung, pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (lung, pituitary gland, tonsil)
GENE INFORMATION
Gene name
BPIFA1 (HGNC Symbol)
Synonyms
bA49G10.5, LUNX, PLUNC, SPLUNC1
Description
BPI fold containing family A, member 1 (HGNC Symbol)
Entrez gene summary
This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known. [provided by RefSeq, Aug 2014]
Q9NP55 [Direct mapping] BPI fold-containing family A member 1
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0008289 [lipid binding] GO:0019731 [antibacterial humoral response] GO:0045087 [innate immune response] GO:0050828 [regulation of liquid surface tension] GO:0050891 [multicellular organismal water homeostasis] GO:1900229 [negative regulation of single-species biofilm formation in or on host organism] GO:1902305 [regulation of sodium ion transmembrane transport]
Q9NP55 [Direct mapping] BPI fold-containing family A member 1
Show all
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0008289 [lipid binding] GO:0019731 [antibacterial humoral response] GO:0045087 [innate immune response] GO:0050828 [regulation of liquid surface tension] GO:0050891 [multicellular organismal water homeostasis] GO:1900229 [negative regulation of single-species biofilm formation in or on host organism] GO:1902305 [regulation of sodium ion transmembrane transport]
Q9NP55 [Direct mapping] BPI fold-containing family A member 1
Show all
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0008289 [lipid binding] GO:0019731 [antibacterial humoral response] GO:0045087 [innate immune response] GO:0050828 [regulation of liquid surface tension] GO:0050891 [multicellular organismal water homeostasis] GO:1900229 [negative regulation of single-species biofilm formation in or on host organism] GO:1902305 [regulation of sodium ion transmembrane transport]
