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HSD17B11

GENERAL INFORMATION

Gene name

 HSD17B11

Gene description

 Hydroxysteroid (17-beta) dehydrogenase 11

Protein class

 Enzymes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (CAPAN-2)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA021608
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021608

GENE INFORMATION

Gene name

 HSD17B11 (HGNC Symbol)

Synonyms

 17-BETA-HSD11, 17-BETA-HSDXI, DHRS8, PAN1B, RetSDR2, SDR16C2

Description

 Hydroxysteroid (17-beta) dehydrogenase 11 (HGNC Symbol)

Entrez gene summary

 Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]

Chromosome

 4

Cytoband

 q22.1

Chromosome location (bp)

 87336610 - 87391386

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198189 (version 83.38)

Entrez gene

 51170

UniProt

 Q8NBQ5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NBQ5

Antibodypedia

 HSD17B11 antibodies

PROTEIN BROWSER
HSD17B11-001
HSD17B11-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HSD17B11-001
ENSP00000351035
ENST00000358290
Q8NBQ5 [Direct mapping]
Estradiol 17-beta-dehydrogenase 11
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004303 [estradiol 17-beta-dehydrogenase activity]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0006703 [estrogen biosynthetic process]
GO:0006710 [androgen catabolic process]
GO:0008152 [metabolic process]
GO:0008202 [steroid metabolic process]
GO:0016229 [steroid dehydrogenase activity]
GO:0016491 [oxidoreductase activity]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
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 300 aa
33 kDa 		Yes 0
HSD17B11-003
ENSP00000423775
ENST00000507286
D6RCD0 [Direct mapping]
Estradiol 17-beta-dehydrogenase 11
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 256 aa
28.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.