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CACNA1E
  • TISSUE

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TISSUE ATLAS

GENE/PROTEIN

Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CACNA1E

Gene description

Calcium channel, voltage-dependent, R type, alpha 1E subunit

Protein class

Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

Membrane

Number of transcripts

9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus)
FANTOM5:Tissue enhanced (caudate, hippocampus)

Protein evidence

Evidence at protein level

DATA RELIABILITY

Reliability score

Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
N/A
Cerebral cortex
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Thyroid gland
N/A
Parathyroid gland
N/A
Adrenal gland
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Bone marrow
N/A
Lymph node
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Heart muscle
N/A
Skeletal muscle
N/A
Smooth muscle
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Gallbladder
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Salivary gland
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Small intestine
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
Prostate
N/A
Seminal vesicle
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
Endometrium
N/A
Fallopian tube
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Adipose tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW

Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, hippocampus)

GENE INFORMATION

Gene name

CACNA1E (HGNC Symbol)

Synonyms

BII, CACH6, CACNL1A6, Cav2.3

Description

Calcium channel, voltage-dependent, R type, alpha 1E subunit (HGNC Symbol)

Entrez gene summary

Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]

Chromosome

1

Cytoband

q25.3

Chromosome location (bp)

181413102 - 181808084

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198216 (version 83.38)

Entrez gene

777

UniProt

Q15878 (UniProt - Evidence at protein level)

neXtProt

NX_Q15878

Antibodypedia

CACNA1E antibodies

PROTEIN BROWSER

CACNA1E-001
CACNA1E-002
CACNA1E-003
CACNA1E-004
CACNA1E-006
CACNA1E-201
CACNA1E-202
CACNA1E-203
CACNA1E-204

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CACNA1E-001
ENSP00000356542
ENST00000367570
Q15878 [Direct mapping]
Voltage-dependent R-type calcium channel subunit alpha-1E
Show all
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0007268 [synaptic transmission]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0044281 [small molecule metabolic process]
GO:0050796 [regulation of insulin secretion]
GO:0051899 [membrane depolarization]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0086010 [membrane depolarization during action potential]
Show all
2270 aa
257.1 kDa
No >9
CACNA1E-002
ENSP00000481619
ENST00000621791
Q15878 [Direct mapping]
Voltage-dependent R-type calcium channel subunit alpha-1E
Show all
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0007268 [synaptic transmission]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0044281 [small molecule metabolic process]
GO:0050796 [regulation of insulin secretion]
GO:0051899 [membrane depolarization]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0086010 [membrane depolarization during action potential]
Show all
2251 aa
254.6 kDa
No >9
CACNA1E-003
ENSP00000356545
ENST00000367573
Q15878 [Direct mapping]
Voltage-dependent R-type calcium channel subunit alpha-1E
Show all
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0001662 [behavioral fear response]
GO:0002027 [regulation of heart rate]
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0007268 [synaptic transmission]
GO:0007626 [locomotory behavior]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0008542 [visual learning]
GO:0016020 [membrane]
GO:0019226 [transmission of nerve impulse]
GO:0019233 [sensory perception of pain]
GO:0030317 [sperm motility]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042593 [glucose homeostasis]
GO:0042596 [fear response]
GO:0044281 [small molecule metabolic process]
GO:0048265 [response to pain]
GO:0048266 [behavioral response to pain]
GO:0050796 [regulation of insulin secretion]
GO:0050877 [neurological system process]
GO:0051899 [membrane depolarization]
GO:0055085 [transmembrane transport]
GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0090273 [regulation of somatostatin secretion]
Show all
2313 aa
261.7 kDa
No >9
CACNA1E-004
ENSP00000432038
ENST00000524607
E9PIE8 [Direct mapping]
Voltage-dependent R-type calcium channel subunit alpha-1E
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
438 aa
49.3 kDa
No 6
CACNA1E-006
ENSP00000353222
ENST00000360108
F8W9Z1 [Direct mapping]
Voltage-dependent R-type calcium channel subunit alpha-1E
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
2294 aa
259.2 kDa
No >9
CACNA1E-201
ENSP00000350183
ENST00000357570
J3KP11 [Direct mapping]
Voltage-dependent R-type calcium channel subunit alpha-1E
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
2312 aa
261.9 kDa
No >9
CACNA1E-202
ENSP00000351101
ENST00000358338
Q15878 [Direct mapping]
Voltage-dependent R-type calcium channel subunit alpha-1E
Show all
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0007268 [synaptic transmission]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0044281 [small molecule metabolic process]
GO:0050796 [regulation of insulin secretion]
GO:0051899 [membrane depolarization]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0086010 [membrane depolarization during action potential]
Show all
2251 aa
254.6 kDa
No >9
CACNA1E-203
ENSP00000356539
ENST00000367567
Q15878 [Direct mapping]
Voltage-dependent R-type calcium channel subunit alpha-1E
Show all
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0007268 [synaptic transmission]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0044281 [small molecule metabolic process]
GO:0050796 [regulation of insulin secretion]
GO:0051899 [membrane depolarization]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0086010 [membrane depolarization during action potential]
Show all
2270 aa
257.1 kDa
No >9
CACNA1E-204
ENSP00000483914
ENST00000621551
Q15878 [Direct mapping]
Voltage-dependent R-type calcium channel subunit alpha-1E
Show all
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0007268 [synaptic transmission]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0044281 [small molecule metabolic process]
GO:0050796 [regulation of insulin secretion]
GO:0051899 [membrane depolarization]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0086010 [membrane depolarization during action potential]
Show all
2313 aa
261.7 kDa
No >9

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