Tissue expression of TMEM116 - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

TMEM116

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TMEM116
Gene description	Transmembrane protein 116
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	9
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (parathyroid gland)
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at transcript level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA040720
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (parathyroid gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	TMEM116 (HGNC Symbol)
Synonyms	FLJ90167
Description	Transmembrane protein 116 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q24.13
Chromosome location (bp)	111931282 - 112013185
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000198270 (version 83.38)
Entrez gene	89894
UniProt	Q8NCL8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NCL8
Antibodypedia	TMEM116 antibodies

PROTEIN BROWSER

TMEM116-001	TMEM116-003	TMEM116-005	TMEM116-007	TMEM116-009	TMEM116-010	TMEM116-012	TMEM116-013	TMEM116-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM116-001 ENSP00000447731 ENST00000552374	Q8NCL8 [Direct mapping] Transmembrane protein 116 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] Show all	337 aa 38 kDa	No	4
TMEM116-003 ENSP00000449163 ENST00000549537	G3V1Z3 [Direct mapping] Transmembrane protein 116; Transmembrane protein 116, isoform CRA_c Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	151 aa 17.3 kDa	No	1
TMEM116-005 ENSP00000450377 ENST00000550831	Q8NCL8 [Direct mapping] Transmembrane protein 116 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] Show all	245 aa 27.5 kDa	No	2
TMEM116-007 ENSP00000347620 ENST00000355445	Q8NCL8 [Direct mapping] Transmembrane protein 116 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] Show all	302 aa 33.8 kDa	Yes	3
TMEM116-009 ENSP00000450060 ENST00000550233	F8VQZ8 [Direct mapping] Transmembrane protein 116 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all		51 aa 5.8 kDa	Yes	1
TMEM116-010 ENSP00000449774 ENST00000549425	F8VWU6 [Direct mapping] Transmembrane protein 116 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	106 aa 12 kDa	No	1
TMEM116-012 ENSP00000446516 ENST00000550037	F8VNZ8 [Direct mapping] Transmembrane protein 116 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	175 aa 19.6 kDa	No	2
TMEM116-013 ENSP00000446766 ENST00000546962	F8W1L7 [Direct mapping] Transmembrane protein 116 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		74 aa 8.1 kDa	Yes	0
TMEM116-014 ENSP00000474027 ENST00000550800	S4R388 [Direct mapping] Transmembrane protein 116 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	104 aa 11.4 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.