Cell atlas - PIM3 - The Human Protein Atlas

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PIM3

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	PIM3
Gene description	Pim-3 proto-oncogene, serine/threonine kinase
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA068758
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA068758	HEK 293	Cytosol
	HPA068758	SK-MEL-30	Cytosol
	HPA068758	U-2 OS	Cytosol

GENE INFORMATION
Gene name	PIM3
Synonyms
Description	Pim-3 proto-oncogene, serine/threonine kinase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis. [provided by RefSeq, Jun 2012]
Chromosome	22
Cytoband	q13.33
Chromosome location (bp)	49960513 - 49964080
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198355 (version 83.38)
Entrez gene	415116
UniProt	Q86V86 (UniProt - Evidence at protein level)
neXtProt	NX_Q86V86
Antibodypedia	PIM3 antibodies

PROTEIN BROWSER

PIM3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PIM3-001 ENSP00000353824 ENST00000360612	Q86V86 [Direct mapping] Serine/threonine-protein kinase pim-3 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007049 [cell cycle] GO:0007346 [regulation of mitotic cell cycle] GO:0043066 [negative regulation of apoptotic process] GO:0046777 [protein autophosphorylation] GO:0061179 [negative regulation of insulin secretion involved in cellular response to glucose stimulus] Show all	326 aa 35.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.