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ASNA1

GENERAL INFORMATION

Gene name

 ASNA1

Gene description

 ArsA arsenite transporter, ATP-binding, homolog 1 (bacterial)

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA045951
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), urothelial cancer (unfavourable) and cervical cancer (favourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045951

GENE INFORMATION

Gene name

 ASNA1 (HGNC Symbol)

Synonyms

 ARSA-I, GET3, TRC40

Description

 ArsA arsenite transporter, ATP-binding, homolog 1 (bacterial) (HGNC Symbol)

Entrez gene summary

 This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011]

Chromosome

 19

Cytoband

 p13.13

Chromosome location (bp)

 12737139 - 12748323

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198356 (version 83.38)

Entrez gene

 439

UniProt

 O43681 (UniProt - Evidence at protein level)

neXtProt

 NX_O43681

Antibodypedia

 ASNA1 antibodies

PROTEIN BROWSER
ASNA1-001
ASNA1-002
ASNA1-201
ASNA1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ASNA1-001
ENSP00000466379
ENST00000591090
O43681 [Direct mapping]
ATPase ASNA1
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Transporters
   Primary Active Transporters
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006810 [transport]
GO:0015105 [arsenite transmembrane transporter activity]
GO:0015698 [inorganic anion transport]
GO:0016887 [ATPase activity]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0044267 [cellular protein metabolic process]
GO:0045048 [protein insertion into ER membrane]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
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 348 aa
38.8 kDa 		No 0
ASNA1-002
ENSP00000468450
ENST00000586561
K7ERW9 [Direct mapping]
ATPase ASNA1
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
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 200 aa
21.9 kDa 		No 0
ASNA1-201
ENSP00000349887
ENST00000357332
O43681 [Direct mapping]
ATPase ASNA1
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Transporters
   Primary Active Transporters
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006810 [transport]
GO:0015105 [arsenite transmembrane transporter activity]
GO:0015698 [inorganic anion transport]
GO:0016887 [ATPase activity]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0044267 [cellular protein metabolic process]
GO:0045048 [protein insertion into ER membrane]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
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 348 aa
38.8 kDa 		No 0
ASNA1-202
ENSP00000481254
ENST00000611688
A0A087WXS7 [Direct mapping]
ATPase ASNA1
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005783 [endoplasmic reticulum]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
GO:0045048 [protein insertion into ER membrane]
GO:0046872 [metal ion binding]
Show all
 331 aa
37.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.