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Cell lines sorted after organ of phenotypic resemblance.
Cell lines sorted after biological source for establishment.
Cell lines sorted after the cell line category according to Cellosaurus.
Cell lines sorted on descending RNA expression.
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GENE INFORMATION
Gene name
WWP2 (HGNC Symbol)
Synonyms
AIP2
Description
WW domain containing E3 ubiquitin protein ligase 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012]
MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000151 [ubiquitin ligase complex] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006464 [cellular protein modification process] GO:0008134 [transcription factor binding] GO:0010629 [negative regulation of gene expression] GO:0016020 [membrane] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0032410 [negative regulation of transporter activity] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046718 [viral entry into host cell] GO:0051224 [negative regulation of protein transport] GO:0051865 [protein autoubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0070062 [extracellular exosome] GO:0070534 [protein K63-linked ubiquitination] GO:1901016 [regulation of potassium ion transmembrane transporter activity]
MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000151 [ubiquitin ligase complex] GO:0001085 [RNA polymerase II transcription factor binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006464 [cellular protein modification process] GO:0008134 [transcription factor binding] GO:0010629 [negative regulation of gene expression] GO:0016020 [membrane] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0032410 [negative regulation of transporter activity] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046718 [viral entry into host cell] GO:0051224 [negative regulation of protein transport] GO:0051865 [protein autoubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0070062 [extracellular exosome] GO:0070534 [protein K63-linked ubiquitination] GO:1901016 [regulation of potassium ion transmembrane transporter activity]
