Expression of B3GNT6 in cancer - Summary - The Human Protein Atlas

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B3GNT6

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	B3GNT6
Gene description	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (colorectal cancer, lung cancer, pancreatic cancer, prostate cancer, stomach cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (colon, rectum, stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in goblet cells in gastrointestinal mucosa.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA039805
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (colorectal cancer, lung cancer, pancreatic cancer, prostate cancer, stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039805

GENE INFORMATION
Gene name	B3GNT6 (HGNC Symbol)
Synonyms	B3Gn-T6
Description	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q13.5
Chromosome location (bp)	77034398 - 77041973
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198488 (version 83.38)
Entrez gene	192134
UniProt	Q6ZMB0 (UniProt - Evidence at protein level)
neXtProt	NX_Q6ZMB0
Antibodypedia	B3GNT6 antibodies

PROTEIN BROWSER

B3GNT6-001	B3GNT6-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
B3GNT6-001 ENSP00000484640 ENST00000622824	Q6ZMB0 [Direct mapping] Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase A8K9Q8 [Target identity:100%; Query identity:100%] HCG2018639; cDNA FLJ78031, highly similar to Homo sapiens beta3GnT6 beta-1,3-N- acetylglucosaminyltransferase 6; cDNA, FLJ94270, Homo sapiens beta-1,3-N-acetylglucosaminyltransferase protein(IMAGE:4907098), mRNA Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0006486 [protein glycosylation] GO:0006493 [protein O-linked glycosylation] GO:0008378 [galactosyltransferase activity] GO:0009101 [glycoprotein biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0016269 [O-glycan processing, core 3] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0047223 [beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity] GO:0047224 [acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity] Show all	384 aa 42.7 kDa	Yes	0
B3GNT6-003 ENSP00000435628 ENST00000528622	E9PJ79 [Direct mapping] UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008378 [galactosyltransferase activity] GO:0016020 [membrane] Show all	121 aa 13.3 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.