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NUDT16

GENERAL INFORMATION

Gene name

 NUDT16

Gene description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 16

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nucleolar expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA060452 , HPA062492
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and cervical cancer (favourable).
Renal cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA060452
HPA062492

GENE INFORMATION

Gene name

 NUDT16 (HGNC Symbol)

Synonyms

 FLJ31265

Description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 16 (HGNC Symbol)

Entrez gene summary

Chromosome

 3

Cytoband

 q22.1

Chromosome location (bp)

 131381671 - 131388830

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198585 (version 83.38)

Entrez gene

 131870

UniProt

 Q96DE0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96DE0

Antibodypedia

 NUDT16 antibodies

PROTEIN BROWSER
NUDT16-001
NUDT16-002
NUDT16-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUDT16-001
ENSP00000429274
ENST00000521288
Q96DE0 [Direct mapping]
U8 snoRNA-decapping enzyme
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003729 [mRNA binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006382 [adenosine to inosine editing]
GO:0006402 [mRNA catabolic process]
GO:0006508 [proteolysis]
GO:0008235 [metalloexopeptidase activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0016077 [snoRNA catabolic process]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0030145 [manganese ion binding]
GO:0030515 [snoRNA binding]
GO:0034656 [nucleobase-containing small molecule catabolic process]
GO:0035863 [dITP catabolic process]
GO:0035870 [dITP diphosphatase activity]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0046709 [IDP catabolic process]
GO:0050072 [m7G(5')pppN diphosphatase activity]
GO:0050897 [cobalt ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0090068 [positive regulation of cell cycle process]
GO:0090450 [inosine-diphosphatase activity]
GO:0097383 [dIDP diphosphatase activity]
GO:0098519 [nucleotide phosphatase activity, acting on free nucleotides]
GO:1901639 [XDP catabolic process]
GO:1901640 [XTP binding]
GO:1901641 [ITP binding]
GO:2000233 [negative regulation of rRNA processing]
GO:2000781 [positive regulation of double-strand break repair]
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 195 aa
21.3 kDa 		No 0
NUDT16-002
ENSP00000422375
ENST00000502852
Q96DE0 [Direct mapping]
U8 snoRNA-decapping enzyme
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003729 [mRNA binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006382 [adenosine to inosine editing]
GO:0006402 [mRNA catabolic process]
GO:0006508 [proteolysis]
GO:0008235 [metalloexopeptidase activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0016077 [snoRNA catabolic process]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0030145 [manganese ion binding]
GO:0030515 [snoRNA binding]
GO:0034656 [nucleobase-containing small molecule catabolic process]
GO:0035863 [dITP catabolic process]
GO:0035870 [dITP diphosphatase activity]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0046709 [IDP catabolic process]
GO:0050072 [m7G(5')pppN diphosphatase activity]
GO:0050897 [cobalt ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0090068 [positive regulation of cell cycle process]
GO:0090450 [inosine-diphosphatase activity]
GO:0097383 [dIDP diphosphatase activity]
GO:0098519 [nucleotide phosphatase activity, acting on free nucleotides]
GO:1901639 [XDP catabolic process]
GO:1901640 [XTP binding]
GO:1901641 [ITP binding]
GO:2000233 [negative regulation of rRNA processing]
GO:2000781 [positive regulation of double-strand break repair]
Show all
 227 aa
25.3 kDa 		No 0
NUDT16-201
ENSP00000440230
ENST00000537561
Q96DE0 [Direct mapping]
U8 snoRNA-decapping enzyme
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003729 [mRNA binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006382 [adenosine to inosine editing]
GO:0006402 [mRNA catabolic process]
GO:0006508 [proteolysis]
GO:0008235 [metalloexopeptidase activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0016077 [snoRNA catabolic process]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0030145 [manganese ion binding]
GO:0030515 [snoRNA binding]
GO:0034656 [nucleobase-containing small molecule catabolic process]
GO:0035863 [dITP catabolic process]
GO:0035870 [dITP diphosphatase activity]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0046709 [IDP catabolic process]
GO:0050072 [m7G(5')pppN diphosphatase activity]
GO:0050897 [cobalt ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0090068 [positive regulation of cell cycle process]
GO:0090450 [inosine-diphosphatase activity]
GO:0097383 [dIDP diphosphatase activity]
GO:0098519 [nucleotide phosphatase activity, acting on free nucleotides]
GO:1901639 [XDP catabolic process]
GO:1901640 [XTP binding]
GO:1901641 [ITP binding]
GO:2000233 [negative regulation of rRNA processing]
GO:2000781 [positive regulation of double-strand break repair]
Show all
 159 aa
17.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.