Expression of LRBA in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

LRBA

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LRBA
Gene description	LPS-responsive vesicle trafficking, beach and anchor containing
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues at variable levels.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA019366 , HPA023597
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019366	HPA023597

GENE INFORMATION
Gene name	LRBA (HGNC Symbol)
Synonyms	BGL, CDC4L, LAB300, LBA
Description	LPS-responsive vesicle trafficking, beach and anchor containing (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Chromosome	4
Cytoband	q31.3
Chromosome location (bp)	150264531 - 151015727
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198589 (version 83.38)
Entrez gene	987
UniProt	P50851 (UniProt - Evidence at protein level)
neXtProt	NX_P50851
Antibodypedia	LRBA antibodies

PROTEIN BROWSER

LRBA-001	LRBA-002	LRBA-003	LRBA-008	LRBA-011	LRBA-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRBA-001 ENSP00000421552 ENST00000510413	P50851 [Direct mapping] Lipopolysaccharide-responsive and beige-like anchor protein Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005764 [lysosome] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0008150 [biological_process] GO:0012505 [endomembrane system] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016197 [endosomal transport] GO:0019898 [extrinsic component of membrane] Show all	2851 aa 317.7 kDa	No	0
LRBA-002 ENSP00000349629 ENST00000357115	P50851 [Direct mapping] Lipopolysaccharide-responsive and beige-like anchor protein Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005764 [lysosome] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0008150 [biological_process] GO:0012505 [endomembrane system] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016197 [endosomal transport] GO:0019898 [extrinsic component of membrane] Show all	2863 aa 319.1 kDa	No	0
LRBA-003 ENSP00000426669 ENST00000509835	H0YAC6 [Direct mapping] Lipopolysaccharide-responsive and beige-like anchor protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005622 [intracellular] GO:0012505 [endomembrane system] GO:0016197 [endosomal transport] GO:0019898 [extrinsic component of membrane] Show all	1505 aa 166.8 kDa	No	1
LRBA-008 ENSP00000422180 ENST00000507224	E9PEM5 [Direct mapping] Lipopolysaccharide-responsive and beige-like anchor protein Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005543 [phospholipid binding] GO:0005622 [intracellular] GO:0012505 [endomembrane system] GO:0016197 [endosomal transport] GO:0019898 [extrinsic component of membrane] Show all	2575 aa 287 kDa	No	0
LRBA-011 ENSP00000424640 ENST00000502839	H0Y9N9 [Direct mapping] Lipopolysaccharide-responsive and beige-like anchor protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005543 [phospholipid binding] GO:0005622 [intracellular] GO:0012505 [endomembrane system] GO:0016197 [endosomal transport] GO:0019898 [extrinsic component of membrane] Show all	134 aa 15 kDa	No	0
LRBA-014 ENSP00000425852 ENST00000508606	H0YA17 [Direct mapping] Lipopolysaccharide-responsive and beige-like anchor protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005622 [intracellular] GO:0012505 [endomembrane system] GO:0016197 [endosomal transport] GO:0019898 [extrinsic component of membrane] Show all	147 aa 16.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.