Fields »
ABOUT
HELP
BLOG
MMP17

GENERAL INFORMATION

Gene name

 MMP17

Gene description

 Matrix metallopeptidase 17 (membrane-inserted)

Protein class

 Enzymes
FDA approved drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (melanoma)
HPA (cell line):Group enriched (REH, SK-MEL-30, WM-115)
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (melanoma)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 MMP17 (HGNC Symbol)

Synonyms

 MT4-MMP

Description

 Matrix metallopeptidase 17 (membrane-inserted) (HGNC Symbol)

Entrez gene summary

 Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q24.33

Chromosome location (bp)

 131828393 - 131851783

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198598 (version 83.38)

Entrez gene

 4326

UniProt

 Q9ULZ9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9ULZ9

Antibodypedia

 MMP17 antibodies

PROTEIN BROWSER
MMP17-001
MMP17-002
MMP17-003
MMP17-004
MMP17-005
MMP17-008
MMP17-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MMP17-001
ENSP00000353767
ENST00000360564
Q9ULZ9 [Direct mapping]
Matrix metalloproteinase-17
Show all
Enzymes
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0006954 [inflammatory response]
GO:0008047 [enzyme activator activity]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0031012 [extracellular matrix]
GO:0031225 [anchored component of membrane]
GO:0043085 [positive regulation of catalytic activity]
Show all
 603 aa
66.7 kDa 		Yes 0
MMP17-002
ENSP00000441106
ENST00000535291
Q9ULZ9 [Direct mapping]
Matrix metalloproteinase-17
Show all
Enzymes
   Peptidases
   Metallopeptidases
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0006954 [inflammatory response]
GO:0008047 [enzyme activator activity]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0031012 [extracellular matrix]
GO:0031225 [anchored component of membrane]
GO:0043085 [positive regulation of catalytic activity]
Show all
 519 aa
57.9 kDa 		No 0
MMP17-003
ENSP00000444603
ENST00000545671
F5GZA7 [Direct mapping]
Matrix metalloproteinase-17
Show all
Predicted intracellular proteins
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0006954 [inflammatory response]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0031012 [extracellular matrix]
Show all
 169 aa
18.9 kDa 		No 0
MMP17-004
ENSP00000441710
ENST00000545790
F5GWR3 [Direct mapping]
Matrix metalloproteinase-17
Show all
Predicted intracellular proteins
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0006954 [inflammatory response]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0031012 [extracellular matrix]
Show all
 115 aa
13 kDa 		No 0
MMP17-005
ENSP00000442104
ENST00000534865
F5H881 [Direct mapping]
Matrix metalloproteinase-17
Show all
Predicted intracellular proteins
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0006508 [proteolysis]
GO:0006954 [inflammatory response]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0031012 [extracellular matrix]
Show all
 302 aa
34.7 kDa 		No 0
MMP17-008
ENSP00000439542
ENST00000542648
F5H249 [Direct mapping]
Matrix metalloproteinase-17
Show all
Predicted intracellular proteins
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0006954 [inflammatory response]
GO:0016021 [integral component of membrane]
Show all
 118 aa
14 kDa 		No 0
MMP17-010
ENSP00000445620
ENST00000535004
F5H209 [Direct mapping]
Matrix metalloproteinase-17
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0006954 [inflammatory response]
GO:0016021 [integral component of membrane]
GO:0046872 [metal ion binding]
Show all
 143 aa
14.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.