Expression of BAZ1A in cancer - Summary - The Human Protein Atlas

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BAZ1A

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BAZ1A
Gene description	Bromodomain adjacent to zinc finger domain, 1A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA002730
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA002730

GENE INFORMATION
Gene name	BAZ1A (HGNC Symbol)
Synonyms	ACF1, hACF1, WALp1, WCRF180
Description	Bromodomain adjacent to zinc finger domain, 1A (HGNC Symbol)
Entrez gene summary	The BAZ1A gene encodes the accessory subunit of the ATP-dependent chromatin assembly factor (ACF), a member of the ISWI ('imitation switch') family of chromatin remodeling complexes (summarized by Racki et al., 2009 [PubMed 20033039]).[supplied by OMIM, Apr 2010]
Chromosome	14
Cytoband
Chromosome location (bp)	34752731 - 34875647
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198604 (version 83.38)
Entrez gene	11177
UniProt	Q9NRL2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NRL2
Antibodypedia	BAZ1A antibodies

PROTEIN BROWSER

BAZ1A-001	BAZ1A-002	BAZ1A-008	BAZ1A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BAZ1A-001 ENSP00000371859 ENST00000382422	Q9NRL2 [Direct mapping] Bromodomain adjacent to zinc finger domain protein 1A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006261 [DNA-dependent DNA replication] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0008623 [CHRAC] GO:0016590 [ACF complex] Show all	1556 aa 178.7 kDa	No	0
BAZ1A-002 ENSP00000351555 ENST00000358716	Q9NRL2 [Direct mapping] Bromodomain adjacent to zinc finger domain protein 1A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006261 [DNA-dependent DNA replication] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0008623 [CHRAC] GO:0016590 [ACF complex] Show all	1524 aa 175.4 kDa	No	0
BAZ1A-008 ENSP00000480380 ENST00000556314	A0A087WWN7 [Direct mapping] Bromodomain adjacent to zinc finger domain protein 1A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		218 aa 25 kDa	No	0
BAZ1A-201 ENSP00000353458 ENST00000360310	Q9NRL2 [Direct mapping] Bromodomain adjacent to zinc finger domain protein 1A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000228 [nuclear chromosome] GO:0005515 [protein binding] GO:0006261 [DNA-dependent DNA replication] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0008623 [CHRAC] GO:0016590 [ACF complex] Show all	1556 aa 178.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.